Results 211 to 220 of about 2,926,121 (366)

Geniposidic Acid Targeting FXR “S332 and H447” Mediated Conformational Change to Upregulate CYPs and miR‐19a‐3p to Ameliorate Drug‐Induced Liver Injury

Advanced Science, Volume 12, Issue 15, April 17, 2025.
Drug abuse exacerbates cholesterol and bile acids burden, causing liver injury. Geniposidic acid targets FXR Ser332 and His447, together with SRC2‐3 recruitment and activated FXR nuclear translocation. Geniposidic acid‐activated FXR can upregulate CYPs to accelerate bile acids clearance and activate miR‐19a‐3p to suppress LXR‐mediated cholesterol ...
Minqi Fan, Yuanhang Xu, Bingxin Wu, Jiachan Long, Caihong Liu, Zuhui Liang, Rong Zhang, Zhongqiu Liu, Caiyan Wang   +8 more
wiley   +1 more source

Inhibition of Aberrant Activated Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism

Advanced Science, EarlyView.
LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su, Xuemei Fan, Yaoyao Zou, Guangtao Fu, Shiqi Feng, Xiaoxue Wang, Yongmei Yu, Lin Li, Zhenhua Bian, Rongrong Huang, Linmang Qin, Jiping Chen, Qin Zeng, Kai Yan, Caiyue Gao, Zhexiong Lian, Xin Li, Yang Li   +17 more
wiley   +1 more source

Elevated SPARC Disrupts the Intestinal Barrier Integrity in Crohn's Disease by Interacting with OTUD4 and Activating the MYD88/NF‐κB Pathway

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This study reveals that SPARC activates the MYD88/NF‐κB/MLCK/MLC2 pathway by interacting directly with OTUD4, leading to intestinal barrier damage. In addition, the METTL3‐YTHDF1 axis promotes SPARC expression. Therefore, targeting SPARC or the OTUD4/MYD88/NF‐κB/MLCK/MLC2 axis may provide new insights into the molecular basis of CD and may serve as an ...
Jiayu Wang, Yuxin He, Xingchao Zhu, Jinghan Zhu, Zilin Deng, Huan Zhang, Yanjun Chen, Guangbo Zhang, Tongguo Shi, Weichang Chen   +9 more
wiley   +1 more source

Pan‐Variant SARS‐CoV‐2 Vaccines Induce Protective Immunity by Targeting Conserved Epitopes

Advanced Science, Volume 12, Issue 16, April 24, 2025.
An integrative approach identifies conserved B‐cell and T‐cell epitopes within SARS‐CoV‐2 proteins, redirecting immune responses from variable to conserved regions. These epitopes elicit robust humoral and cellular immunity, neutralizing diverse viral variants. Promiscuous T‐cell epitopes demonstrate cross‐species efficacy, highlighting their potential
Masaud Shah, Sung Ung Moon, Ji‐Yon Shin, Ji‐Hye Choi, Doyoon Kim, Hyun Goo Woo   +5 more
wiley   +1 more source

Nudix Hydrolase 13 Impairs the Initiation of Colorectal Cancer by Inhibiting PKM1 ADP‐Ribosylation

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study identified NUDT13 as a roadblock in the progression from colorectal adenoma to CRC, and revealed that NUDT13 stabilizes PKM1 protein by reducing the PARylation that is catalyzed by PARP1, thereby reprogramming the metabolic propensity of CRC cells.
Jinlong Lin, Yixin Yin, Jinghua Cao, Bingxu Zou, Kai Han, Yufan Chen, Siyu Li, Cijun Huang, Jiewei Chen, Yongrui Lv, Shuidan Xu, Dan Xie, Fengwei Wang   +12 more
wiley   +1 more source

DNA Origami‐Cyanine Nanocomplex for Precision Imaging of KRAS‐Mutant Pancreatic Cancer Cells

Advanced Science, EarlyView.
DNA origami‐cyanine (Do‐Cy) nanocomplexes are synthesized to selectively image KRAS‐mutant pancreatic cancer cells in the highly desmoplastic tumors. This study shows that the Do‐Cy nanocomplexes are preferentially internalized by cancer cells over other stroma cells via KRAS‐dependent macropinocytosis.
Hye‐ran Moon, Yancheng Du, Sae Rome Choi, Seongmin Seo, Cih Cheng, Bennett D. Elzey, Jong Hyun Choi, Bumsoo Han   +7 more
wiley   +1 more source

Epidemiology and production effects of leptospirosis in New Zealand sheep : A thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy In Veterinary Sciences at Massey University, Manawatu, New Zealand [PDF]

, 2016
Vallée, Emilie
core  

Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD‐MASH Transition by Disrupting Carnitine Biosynthesis

Advanced Science, EarlyView.
Takeda G protein‐coupled receptor 5 (TGR5) serves as a central regulator in the metabolic dysfunction‐associated steatotic liver disease (MASLD)/metabolic dysfunction‐associated steatohepatitis (MASH) transition via conjugated lithocholic acid (LCA). Mechanistically, TGR5 orchestrates lipotoxicity‐induced cell death through its interaction with CD36 ...
Senlin Lian, Meixi Lu, Luo Jiajing, Bin Zhang, Yi Fang, Xuran Wang, Minghua Zheng, Yan Ni, Guifang Xu, Yonglin Yang, Runqiu Jiang   +10 more
wiley   +1 more source

Corrigendum:Which is the most preventive measure against tail damage in finisher pigs: tail docking, straw provision or lowered stocking density? (Animal (2017) DOI: 10.1017/S175173111700249X)

, 2018
The original publication of Model 1 within the Results Section contained an error within the last sentence. The sentence should have read as follows; However, the effect of tail docking tended to be higher than the effect of straw provision (P=0.092). The authors apologise for the error.
Larsen, M. L.V., Andersen, H. M.L., Pedersen, L. J.   +2 more
openaire   +1 more source

A Multi‐Objective Molecular Generation Method Based on Pareto Algorithm and Monte Carlo Tree Search

Advanced Science, EarlyView.
Pareto Monte Carlo Tree Search Molecular Generation (PMMG), a molecular generation approach leveraging Monte Carlo Tree Search (MCTS) and Pareto algorithm, efficiently explores the Pareto front in high‐dimensional objective spaces for multi‐objective drug design.
Yifei Liu, Yiheng Zhu, Jike Wang, Renling Hu, Chao Shen, Wanglin Qu, Gaoang Wang, Qun Su, Yuchen Zhu, Yu Kang, Peichen Pan, Chang‐Yu Hsieh, Tingjun Hou   +12 more
wiley   +1 more source