Results 221 to 230 of about 2,926,121 (366)

Does Melatonin Enhance Twin Lamb Survival in Commercial Merino Flocks in Australia? [PDF]

Animals (Basel)
Lowe AM, Kleemann DO, Kelly JM, Thompson AN, Krog J, van Wettere WHEJ, Weaver AC.   +6 more
europepmc   +1 more source

Peptide‐Bound Aflibercept Eye Drops for Treatment of Neovascular Age‐Related Macular Degeneration in Nonhuman Primates

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This article demonstrates that the peptide bxyPenetratin (bxyWP) non‐covalently binds to the anti‐vascular endothelial growth factor (VEGF) protein aflibercept via hydrophobic interactions, enabling noninvasive delivery of aflibercept to the choroid and retina through conjunctival‐scleral pathway and effective inhibition of choroidal neovascularization
Xingyan Fan, Kuan Jiang, Yongqian Zhao, Benjamin TK Lee, Feiyang Geng, Marten E Brelen, Weiyue Lu, Gang Wei   +7 more
wiley   +1 more source

Investigating the mechanism of action of the Mongolian Medicine Areca Thirteen Pill (GY-13) in treating major depressive disorder based on integrated pharmacology. [PDF]

Medicine (Baltimore)
Li H, Hu H, Huang X, Zhang J, Che L, Li X, Bagen H, Qiqige W, Guleng W, Tong H.   +9 more
europepmc   +1 more source

Subcellular Cavitation Bubbles Induce Cellular Mechanolysis and Collective Wound Healing in Ultrasound‐Inflicted Cell Ablation

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This study develops an integrated platform for real‐time, on‐the‐fly imaging of focused ultrasound‐induced cell ablation and responses at cellular and subcellular levels. It reveals that focused ultrasound could induce cellular mechanolysis through subcellular cavitation bubbles growing under confined contact with cells.
Ziyue Bai, Zaimeng Li, Yue Shao
wiley   +1 more source

In silico identification of novel CDK4 inhibitors for retinoblastoma

Chemical Physics Impact
Retinoblastoma is a kind of cancer that mostly affects children's eyes, and this study intends to find drugs that can suppress the protein kinase cyclin-dependent kinase 4 (CDK4).
Mukesh kumar, Vikas Srivastava, Uma Devi, KhemRaj Nackwal, Mohammad Z. Ahmed, Prakash K. Shukla   +5 more
doaj  

Therapeutic effects and potential mechanisms of caffeine on obese polycystic ovary syndrome: bioinformatic analysis and experimental validation. [PDF]

Sci Rep
Bai T, Hu Y, Zhou J, Luo L, Liu Y, Yu C.
europepmc   +1 more source

From De Novo Conceived Small Molecules to Multifunctional Supramolecular Nanoparticles: Dual Biofilm and T3SS Intervention, Enhanced Foliar Affinity, and Effective Rice Disease Control

Advanced Science, EarlyView.
From de novo engineered bioactive molecules BtP27 to the multifunctional supramolecular material BtP27@β‐CD with a sunflower‐shaped morphology: its pragmatic applications in augmenting foliar affinity, disrupting biofilms and T3SS, and managing rice pathologies. Abstract Conventional antimicrobials typically exhibit suboptimal deposition on rice leaves,
Xianfu Mu, Kongjun Liu, Jinghan Yang, Juan Liu, Fengpei Du, Gefei Hao, Peiyi Wang   +6 more
wiley   +1 more source

Characterization of the Molecular Mechanisms Underlying Lurasidone-Induced Acute Manic Episodes in Bipolar Depression: A Network Pharmacology and Molecular Docking Approach. [PDF]

CNS Neurosci Ther
Li C, Yang L, Zhang Q, Zhang Y, Li R, Jia F, Wang L, Ma X, Tian H, Zhuo C.   +9 more
europepmc   +1 more source

RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma

Advanced Science, Volume 12, Issue 16, April 24, 2025.
RFWD3 is identified as a key regulator of cisplatin (DDP) sensitivity in osteosarcoma using a genome‐wide CRISPR screen. RFWD3 promotes PHGDH ubiquitination, enhancing NAD+‐mediated nucleotide biosynthesis. Knocking out RFWD3 sensitized osteosarcoma cells to DDP.
Wenchao Zhang, Chi Yin, Lin Qi, Zhongyue Liu, Ruiling Xu, Chao Tu, Zhihong Li   +6 more
wiley   +1 more source

Pig tail length is associated with the prevalence of tail malformations but not with inflammation of the tail. [PDF]

BMC Vet Res
Egerer C, Gerhards K, Becker S, Engel P, König S, Reiner G.   +5 more
europepmc   +1 more source