Results 241 to 250 of about 2,926,121 (366)

Synthetic Lethality of SHP2 and XIAP Suppresses Proliferation and Metastasis in KRAS‐mutant Nonsmall Cell Lung Cancer

Advanced Science, Volume 12, Issue 15, April 17, 2025.
Embelin cotargets SHP2 to disrupt the SHP2/GRB2/SOS complex, inhibiting cancer‐related signaling pathways such as MAPK, (PI3K)/AKT pathway, and XIAP to induce apoptosis signaling pathway, respectively, leading to synthetic lethality in KRAS‐mutant NSCLC cells both in vivo and in vitro.
Nai‐jie Fu, Yu‐wen Sheng, Zhe Fan, Zhao Wu, Ling‐yu Li, Rui‐ying Xi, Xiao‐ke Shi, Guo‐lin Zhang, Fei Wang   +8 more
wiley   +1 more source

Network pharmacology and experimental validation of Compound Kushen Powder for the treatment of diarrhea in vivo. [PDF]

Vet Anim Sci
Yu B, Zhao Y, Jiang L, Zhou J, Xu H, Lei L, Xu L, Wang X, Bu S.   +8 more
europepmc   +1 more source

Engineering Yarrowia lipolytica to Enhance the Production of Malonic Acid via Malonyl‐CoA Pathway at High Titer

Advanced Science, Volume 12, Issue 12, March 27, 2025.
The non‐conventional oleaginous yeast Y. lipolytica has been genetically engineered to produce malonic acid via malonyl‐CoA pathway through introducing an efficient malonyl‐CoA hydrolase. Advanced metabolic engineering and optimization of fermentation conditions resulted in a malonic acid production yield of 19.1 g L−1 in shaking‐flasks.
Qun Yang, Mengzhen Tian, Ping Dong, Yunying Zhao, Yu Deng   +4 more
wiley   +1 more source

Potentially active aspirin derivative to release nitric oxide: In-vitro, in-vivo and in-silico approaches

Saudi Pharmaceutical Journal
The series of newer salicylate derivatives incorporating nitroxy functionality were synthesized and evaluated for their potential effect in gastrointestinal (GI) related toxicity produced by aspirin. The synthesized compounds (5a-j) were subjected to %NO
Amruta M. Amritkar, Afzal Hussain, Mohammad A. Altamimi, Sumel Ashique, Mohd Usman Mohd Siddique, Sushil Burle, Anwar R. Shaikh, Sameer N. Goyal, Zahid R. Bhat   +8 more
doaj  

Integration of network pharmacology and experimental validation to explore the pharmacological mechanism of andrographolide against asthma. [PDF]

Bioresour Bioprocess
Yu Q, Zhu L, Ding X, Lou Y.
europepmc   +1 more source

N4‐Acetylcytidine‐Mediated CD2BP2‐DT Drives YBX1 Phase Separation to Stabilize CDK1 and Promote Breast Cancer Progression

Advanced Science, Volume 12, Issue 15, April 17, 2025.
The long non‐coding RNA (lncRNA) CD2BP2‐DT is upregulated in breast cancer and correlates with poor patient prognosis. Mechanistically, CD2BP2‐DT drives YBX1 phase separation to stabilize CDK1 and promote breast cancer progression. Moreover, NAT10‐mediated N4‐acetylcytosine (ac4C) modification further enhances CD2BP2‐DT expression.
Hongyu Wang, Bozhi Zhao, Jiayu Zhang, Qunyu Hu, Linlin Zhou, Yinghui Zhang, Yixin Cai, Yuansong Qu, Tao Jiang, Dongwei Zhang   +9 more
wiley   +1 more source

Paclitaxel/Luteolin Coloaded Dual‐Functional Liposomes for Esophageal Cancer Therapy

Advanced Science, EarlyView.
The authors develop a pH‐sensitive aptamer‐modified liposome (EA2‐PSL‐PTX/LUT) to illustrate a strategy for the precise delivery of combinational chemotherapeutic drugs for esophageal squamous cell carcinoma (ESCC) targeted therapy. EA2‐PSL‐PTX/LUT provides efficient co‐loading, tumor targeting, and controlled release of luteolin and paclitaxel ...
Congyong Sun, Fei Xie, Huiyun Zhang, Lulu Feng, Yuting Wang, Chaofan Huang, Zhizhen Cui, Chao Luo, Li Zhang, Qilong Wang   +9 more
wiley   +1 more source

Healing progression of tail docking and ear tag wounds in lambs. [PDF]

Sci Rep
Woods JM, Adcock SJJ.
europepmc   +1 more source

P21‐Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy

Advanced Science, Volume 12, Issue 17, May 8, 2025.
Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li, Ting Liu, Yan Wang, Yangpeng Li, Leiying Liu, James Bae, Yu He, Xian Luo, Zhu Liu, Tangting Chen, Xianhong Ou, Dan Zhang, Huan Lan, Juyi Wan, Yan Wei, Fang Zhao, Xin Wang, Tao Li, Christopher L.‐H. Huang, Chunxiang Zhang, Ming Lei, Xiaoqiu Tan   +21 more
wiley   +1 more source

Immunoinformatics method to design universal multi-epitope nanoparticle vaccine for TGEV S protein. [PDF]

Sci Rep
Li S, Yu J, Xiao C, Li Y.
europepmc   +1 more source