Frontiers in Pharmacology, 2022 Background: Hyperuricemia (HUA) is a metabolic disease caused by reduced excretion or increased production of uric acid. This research aims to study the practical components, active targets, and potential mechanism of the “Radix ginseng (RG)-Ziziphus ...
Hao Zhang +13 more
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PLOS ONECurrently, no safe vaccine against leishmaniasis is available. So far, different control strategies against numerous reservoir hosts and biological vectors have not been environment-friendly and feasible. Hence, employing medicinal components and conventional drugs could be a promising approach to developing novel therapeutic alternatives.
Farzaneh Zarrinkar +10 more
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Synthesis, antimycobacterial evaluation, and molecular docking study of 1,2,4-triazole derivatives
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Fifteen 1,2,4-triazole derivatives were synthesised in this study and their MIC values against Mycobacterium tuberculosis (Mtb) ranged from 2 to 32 μg/mL.
Meng-Yu Xia +5 more
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Molecules, 2019 The object of the study was to estimate the long-lasting effects induced by ammonium glycyrrhizinate (AG) after a single administration in mice using animal models of pain and inflammation together with biochemical and docking studies.
Francesco Maione +8 more
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Experimental GerontologyStroke is a debilitating condition with high morbidity, disability, and mortality that significantly affects the quality of life of patients. In China, the WenYang FuYuan recipe is widely used to treat ischemic stroke. However, the underlying mechanism remains unknown, so exploring the potential mechanism of action of this formula is of great practical
Ding Zhang +7 more
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Screening potential anti-osteoarthritis compounds using molecular docking based on MAPK and NFκB pathways and validating their anti-osteoarthritis effect. [PDF]
PLoS ONEOsteoarthritis is an extremely common disease. However, it lacks effective nonsurgical treatments. Molecular docking has been widely used in drug discovery.
Tian-Wang Zhu, Yu Zheng, Rui-Xin Li
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Preparatory work for the future development of animal based measures for assessing the welfare of pig ‐ Report 2: Preparatory work for the future development of animal based measures for assessing the welfare of weaned, growing and fattening pigs including aspects related to space allowance, floor types, tail biting and need for tail docking [PDF]
EFSA Supporting Publications, 2011 The EFSA Animal Health and Welfare panel is requested to develop several scientific opinions concerning animal based measures to assess the welfare of livestock animals. Before this work can start, it is important that conclusions and recommendations of the EFSA scientific opinions are ...
Hans A.M. Spoolder +3 more
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Investigation of the mechanism of chenodeoxycholic acid in treating acute lung injury through network pharmacology and experimental validation [PDF]
Scientific ReportsNetwork pharmacology and molecular simulation techniques were employed to predict the potential targets and signaling pathways of chenodeoxycholic acid in the treatment of acute lung injury. Subsequently, its therapeutic effects on acute lung injury were
Chong He +3 more
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Ecotoxicology and Environmental SafetyFluoride is an essential trace element required for normal physiological functions and holds significant importance for human health. However, excessive fluoride intake can lead to renal damage, for which effective prevention and therapeutic strategies remain scarce.
Xiaoyue Zhang +8 more
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