Results 21 to 30 of about 123,945 (213)

Integrate Molecular Docking and Animal Model Validation into the Research of the Effect and Potential Mechanism of Eupatilin Against Myocardial Ischemia/Reperfusion Injury

Pharmacognosy Magazine
Background Myocardial ischemia/reperfusion (I/R) injury refers to myocardial tissue damage caused by blood reperfusion after acute heart ischemia caused by coronary artery thrombosis and others. This process is closely related to inflammation and endoplasmic reticulum (ER) stress, and there is currently no ideal ...
Yulong Li, Xiang Li
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Anti-hyperalgesic effect of Lippia grata leaf essential oil complexed with β-cyclodextrin in a chronic musculoskeletal pain animal model: Complemented with a molecular docking and antioxidant screening

Biomedicine & Pharmacotherapy, 2017
Due to its unclear pathophysiology, the pharmacological treatment of fibromyalgia is a challenge for researchers. Studies using medicinal plants, such as those from the genus Lippia, complexed with cyclodextrins (CDs) have shown innovative results.The present research intended to evaluate the effect of an inclusion complex containing β-cyclodextrin ...
Pollyana S. Siqueira-Lima, Renan Guedes de Brito, Heitor G. Araújo-Filho, Priscila L. Santos, Angélica Maria Lucchesi, Adriano Antunes de Souza Araújo, Paula dos Passos Menezes, Luciana Scotti, Luciana Scotti, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Gökhan Zengin, Abdurrahman Aktumsek, Ângelo R. Antoniolli, Lucindo José Quíntans-Júnior, Jullyana de Souza Siqueira Quintans   +15 more
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Anti-vitiligo Mechanisms of Traditional Chinese Medicine Compound Baqia Danshen Liniment: Network Pharmacology, Molecular Docking, and Animal Model Insights

Pharmacognosy Magazine
Background Vitiligo is a skin condition characterized by depigmentation and has proven difficult to treat. Traditional Chinese medicine (TCM) offers potential therapeutic alternatives. Compound Baqian Danshen Liniment (CBDL) is a multicomponent herbal formula used in TCM.
Jiaxin Wang, Juan Liu, Yahui Wang, Kailibinuer Abulaiti, Weili Sun, Maihesumu Aikemu, Muhebuli Abulizi   +6 more
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Molecular Docking Perspectives on Phytochemicals: Optimizing Dairy Animal Health through Feed Additives

Journal of Biological Sciences
Muhammad Safdar, Yasmeen Junejo, Mehmet Özaslan   +2 more
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Nelumbo nucifera Gaertn. leaves: network pharmacology and molecular docking analysis of active ingredients and their mechanisms of action in treating atherosclerosis

Biotechnology & Biotechnological Equipment, 2022
Atherosclerosis is the pathological basis of cardiovascular and cerebrovascular diseases. Nelumbo nucifera Gaertn. leaves are edible, an effective traditional Chinese medicine in the treatment of atherosclerosis, but its mechanisms of action remain ...
Linhai Wang, Zhuoji Guan, Shaodong Li, Xin Dong, Jialin Jiang, Lingjun Wang, Shaoxiang Xian   +6 more
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Acclimation and Blood Sampling: Effects on Stress Markers in C57Bl/6J Mice

Animals, 2023
Blood sampling in rodents is common practice in scientific studies. Some of the refined methods widely used are the puncture of the saphenous vein or tail vein, or even tail docking.
Nerea Marin, Amparo Moragon, Domingo Gil, Francisco Garcia-Garcia, Viviana Bisbal   +4 more
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Government response to UK Farm Animal Welfare Council report on castration and tail docking of lambs

Animal Welfare, 2009
E Carter
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Ganoderic acid C2 exerts the pharmacological effects against cyclophosphamide-induced immunosuppression: a study involving molecular docking and experimental validation

Scientific Reports, 2023
Triterpenoids, as the main active ingredient of Ganoderma lucidum fermented extract, exert multiple pharmacological activities, including immunomodulatory properties.
Yuchen Liu, Dongsheng Tan, Hong Cui, Jihua Wang   +3 more
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The Mechanism of Mori Folium and Eucommiae Cortex against Cyclophosphamide-Induced Immunosuppression Integrating Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and Experimental Validation

Metabolites, 2023
It has been reported that Mori Folium (MF) and Eucommiae Cortex (EC) exhibit pharmacological effects in the treatment of immunosuppression. However, the mechanism of MF and EC against immunosuppression remains unclear.
Jinde Liu, Qiao Rong, Chunxiao Zhang, Ali Tariq, Lin Li, Yongning Wu, Feifei Sun   +6 more
doaj   +1 more source

Whey-derived peptides interactions with ACE by molecular docking as a potential predictive tool of natural ACE inhibitors [PDF]

, 2020
Several milk/whey derived peptides possess high in vitro angiotensin I-converting enzyme (ACE) inhibitory activity. However, in some cases, poor correlation between the in vitro ACE inhibitory activity and the in vivo antihypertensive activity has been ...
Chamata, Yara, Jauregi, Paula, Watson, Kimberly A.   +2 more
core   +1 more source