Results 21 to 30 of about 135,313 (306)

A–C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions [PDF]

, 2018
Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A–C estrogens, lacking the B and D estrogen rings ...
Donaldson, William A., Frick, Karyn M., Hanson, Alicia M., Imhoff, Andrea, Kim, Jaekyoon, Lu, Xingyun, Mackinnon, Alexander Craig, Pandey, Rajesh K., Perera, K. L. Iresha Sampathi, Sem, Daniel S., Sweeney, Noreena, Van Hart, Rochelle M., Wargolet, Adam J.   +12 more
core   +4 more sources

Effect of previous handling experiences on responses of dairy calves to routine husbandry procedures [PDF]

, 2013
The nature of human–animal interactions is an important factor contributing to animal welfare and productivity. Reducing stress during routine husbandry procedures is likely to improve animal welfare.
McLeay, Lance M., Schütz, K.E., Shepherd, Haley Marie, Stewart, Mairi, Waas, Joseph R., Webster, J.R.   +5 more
core   +2 more sources

Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases PDI and ERp5 [PDF]

, 2020
Background: Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid.
Ayyanar, Banno, Bekendam, Bi, Chagas, Chagas, Chang, Chen, Chung, Dang, De Bona, Dutta-Roy, Essex, Essex, Essex, Ghoshal, Giamogante, Giamogante, Holbrook, Inoue, Jarvis, Jasuja, Jayakumar, Jordan, Kang, Kehrel, Kim, Lahav, Lakowicz, Lescano, Lin, Lu, Mangin, Masuda, Navarro-Nuñez, Park, Raffaelli, Raturi, Sharma, Sousa, Stopa, Taylor, Trnkova, Wang, Ware, Wendelboe   +45 more
core   +1 more source

Exploring the mechanism of anti-fatigue of resveratrol based on network pharmacology and molecular docking, and in vitro studies

Scientific Reports, 2023
To investigate the potential mechanism of resveratrol in anti-fatigue by network pharmacology and molecular docking, and to investigate the anti-fatigue efficacy of resveratrol through in vitro animal experiments.
Peipei Ma, Jinlei Li, Qing Huang, Shijie Wei, Hurong Ge, Zhizhong Wang   +5 more
doaj   +1 more source

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma. [PDF]

, 2019
Dysregulation of the seven-transmembrane (7TM) receptor Smoothened (SMO) and other components of the Hedgehog (Hh) signaling pathway contributes to the development of cancers including basal cell carcinoma (BCC) and medulloblastoma (MB).
Abagyan, Ruben, Chahal, Kirti Kandhwal, Chen, Clark C, Durden, Donald L, Kufareva, Irina, Li, Jie, Parle, Milind, Wechsler-Reya, Robert J   +7 more
core   +1 more source

Improved effect of fresh ginseng paste (radix ginseng-ziziphus jujube) on hyperuricemia based on network pharmacology and molecular docking

Frontiers in Pharmacology, 2022
Background: Hyperuricemia (HUA) is a metabolic disease caused by reduced excretion or increased production of uric acid. This research aims to study the practical components, active targets, and potential mechanism of the “Radix ginseng (RG)-Ziziphus ...
Hao Zhang, Hao Zhang, Wei Liu, Wei Liu, Si-Min Qi, Si-Min Qi, Jian-Feng Chi, Qiang Gao, Xiang-Hui Lin, Shen Ren, Zi Wang, Xiu-juan Lei, Wei Li, Wei Li   +13 more
doaj   +1 more source

A perception-action strategy for hummingbirds [PDF]

, 2010
Many human and animal tasks are thought to be controlled with the tau informational variable. It is widely accepted that controlling the rate of change of tau during decelerative tasks, such as when braking or landing, is one common perceptual control ...
Delafield-Butt, Jonathan, Galler, Andreas, Lee, David, Schögler, Benjaman   +3 more
core   +2 more sources

Antinociceptive Activity of Macaranga denticulata Muell. Arg. (Family: Euphorbiaceae): In Vivo and In Silico Studies

Medicines, 2017
Background: The present study was conducted to investigate the antinociceptive activity of methanol extract of Macaranga denticulata (Met.MD) in an animal model, followed by molecular docking analysis.
Abul Hasanat, Tanvir Ahmad Chowdhury, Mohammad Shah Hafez Kabir, Mohammed Sohel Chowdhury, Md. Nazim Uddin Chy, Jackie Barua, Nishan Chakrabarty, Arkajyoti Paul   +7 more
doaj   +1 more source

Review: The tale of the Finnish pig tail – how to manage non-docked pigs?

Animal, 2022
Tail biting is a serious behavioural problem in modern pig production, causing impaired animal welfare and economic losses. In most countries, the detrimental effects of tail biting are counteracted by docking pigs tails.
A. Valros
doaj   +1 more source

Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates [PDF]

, 2016
Fentanyl is a powerful opiate analgesic typically used for the treatment of severe and chronic pain, but its prescription is strongly limited by the well-documented side-effects.
Benyhe, Sa ́ndor, CARRADORI, Simone, Csaba To ̈mbo ̈ly, Erdei, Anna I., Ferenc O. ̈tvos, Ferenc Za ́dor, Fidanza, Lorenzo, Marzoli, Francesca, Mirzaie, Sako, MOLLICA, Adriano, MONTI, LUDOVICA, Moriello, Aniello Schiano, Novellino, Ettore, Petrocellis, Luciano De, PIERETTI, stefano, Samavati, Reza, STEFANUCCI, AZZURRA, Szabolcs Dvora ́csko, Szucs, Edina   +18 more
core   +1 more source