Results 51 to 60 of about 2,926,121 (366)

Design, synthesis and evaluation of novel 3,5-disubstituted benzamide derivatives as allosteric glucokinase activators

open access: yesBMC Chemistry, 2019
Glucokinase (GK) is the key enzyme expressed in β-cells of pancreas and liver hepatocytes and helps in the maintenance of blood glucose levels in normal range.
Ajmer Singh Grewal   +4 more
doaj   +1 more source

Analysis of Housing Risk Factors for the Welfare of Lean and Heavy Pigs in a Sample of European Fattening Farms

open access: yesAnimals, 2021
Pig welfare is affected by housing conditions, the minimum requirements of which are set up by EU legislation. Animal and non-animal-based measures are useful indicators to investigate housing risk factors for pig welfare.
Paolo Ferrari   +2 more
doaj   +1 more source

Docking and Undocking a Modular Underactuated Oscillating Swimming Robot [PDF]

open access: yes, 2021
We describe a docking mechanism and strategy to allow modular self-assembly for the Modboat: an inexpensive underactuated oscillating swimming robot powered by a single motor. Because propulsion is achieved through oscillation, orientation can be controlled only in the average; this complicates docking, which requires precise position and orientation ...
arxiv   +1 more source

Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB [PDF]

open access: yes, 2013
Cysteine proteases of the papain superfamily are present in nearly all eukaryotes. They play pivotal roles in the biology of parasites and inhibition of cysteine proteases is emerging as an important strategy to combat parasitic diseases such as sleeping
Coombs, Graham H   +5 more
core   +1 more source

Ecdysteroids: A novel class of anabolic agents? [PDF]

open access: yes, 2015
Increasing numbers of dietary supplements with ecdysteroids are marketed as “natural anabolic agents”. Results of recent studies suggested that their anabolic effect is mediated by estrogen receptor (ER) binding. Within this study the anabolic potency of
BOTRE', Francesco   +5 more
core   +2 more sources

Harmonization of welfare standards for the protection of pigs with the EU-rules: the case of Croatia [PDF]

open access: yes, 2009
Three quarters of Croatian pigs are produced in small production units (1-5 sows) and on family farms with mixed farming activities. Only few farms have specialized production units with up-to-date technologies and comply with EU standards.
Antunovic, B.   +4 more
core   +2 more sources

Highly flexible protein-peptide docking using CABS-dock [PDF]

open access: yesOra Schueler-Furman and Nir London (eds.), Modeling Peptide-Protein Interactions: Methods and Protocols, Methods in Molecular Biology, vol. 1561, 2017, 2016
Protein-peptide molecular docking is a difficult modeling problem. It is even more challenging when significant conformational changes that may occur during the binding process need to be predicted. In this chapter, we demonstrate the capabilities and features of the CABS-dock server for flexible protein-peptide docking.
arxiv   +1 more source

In Vivo Antinociceptive, Muscle Relaxant, Sedative, and Molecular Docking Studies of Peshawaraquinone Isolated from Fernandoa adenophylla (Wall. ex G. Don) Steenis

open access: yesACS Omega, 2021
Fernandoa adenophylla (Wall. ex G. Don) Steenis is traditionally used to cure various diseases and can be included as an ingredient in massage oils, which are supposed to comfort muscular tension and pain.
F. Alhumaydhi   +7 more
semanticscholar   +1 more source

Discovery of orexant and anorexant agents with indazole scaffold endowed with peripheral antiedema activity [PDF]

open access: yes, 2019
CB1 receptors and endocannabinoids are integrated components of neuronal networks controlling different organism’s functions, such as appetite and food intake in the hypothalamus.
Dimmito, Marilisa P.   +7 more
core   +2 more sources

Antinociceptive Activity of Macaranga denticulata Muell. Arg. (Family: Euphorbiaceae): In Vivo and In Silico Studies

open access: yesMedicines, 2017
Background: The present study was conducted to investigate the antinociceptive activity of methanol extract of Macaranga denticulata (Met.MD) in an animal model, followed by molecular docking analysis.
Abul Hasanat   +7 more
doaj   +1 more source

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