Results 61 to 70 of about 2,947,274 (350)

Docking-based virtual screening of known drugs against murE of Mycobacterium tuberculosis towards repurposing for TB. [PDF]

open access: yes, 2016
Repurposing has gained momentum globally and become an alternative avenue for drug discovery because of its better success rate, and reduced cost, time and issues related to safety than the conventional drug discovery process.
Brindha, Sridharan   +4 more
core   +1 more source

Discovery of potential SARS-CoV 3CL protease inhibitors from approved antiviral drugs using: virtual screening, molecular docking, pharmacophore mapping evaluation and dynamics simulation

open access: yesJournal of Biomolecular Structure and Dynamics, 2021
The spread of corona-virus disease 2019 (COVID-19) has been faster than any other corona-viruses that have succeeded in crossing the animal-human barrier. This disease, caused by the severe acute respiratory syndrome corona-virus 2 (SARS-CoV-2/2019-nCoV)
I. Daoud   +4 more
semanticscholar   +1 more source

Exploring the Interactions Between Caffeic Acid and Human Serum Albumin Using Spectroscopic and Molecular Docking Techniques

open access: yes, 2021
* Corresponding Author: E-mail: r.amarowicz@pan.olsztyn.pl (R. Amarowicz) larly abundant source of this compound [El-Seedi et al., 2012; Pirjo et al., 2006; Tomašević et al., 2019]. In fruits, it may constitute up to 70% of the total HCAs content [Sova &
Ali Jahanban-Esfahlan   +4 more
semanticscholar   +1 more source

Study on the Mechanism of Baimai Ointment in the Treatment of Osteoarthritis Based on Network Pharmacology and Molecular Docking with Experimental Verification

open access: yesFrontiers in Genetics, 2021
Purpose: The external preparation of the Tibetan medicine formula, Baimai ointment (BMO), has great therapeutic effects on osteoarthritis (OA). However, its molecular mechanism remains almost elusive.
Yi-Lin Zhu   +4 more
semanticscholar   +1 more source

Discovery of orexant and anorexant agents with indazole scaffold endowed with peripheral antiedema activity [PDF]

open access: yes, 2019
CB1 receptors and endocannabinoids are integrated components of neuronal networks controlling different organism’s functions, such as appetite and food intake in the hypothalamus.
Dimmito, Marilisa P.   +7 more
core   +2 more sources

DmCatD, a cathepsin D-like peptidase of the hematophagous insect Dipetalogaster maxima (Hemiptera: Reduviidae): Purification, bioinformatic analyses and the significance of its interaction with lipophorin in the internalization by developing oocytes [PDF]

open access: yes, 2018
DmCatD, a cathepsin D-like peptidase of the hematophagous insect Dipetalogaster maxima, is synthesized by the fat body and the ovary and functions as yolk protein precursor. Functionally, DmCatD is involved in vitellin proteolysis.
Arrese, Estela L.   +8 more
core   +1 more source

Lamb behaviour during and shortly after tail-docking

open access: yesSouth African Journal of Animal Science
Routine husbandry procedures for lambs are increasingly scrutinised for their animal welfare implications. One such procedure is tail-docking, which is commonly performed to prevent breech blowfly strike.
M Teubes   +3 more
doaj   +1 more source

On-Farm Welfare Assessment Protocol for Suckling Piglets: A Pilot Study

open access: yesAnimals, 2020
Piglets experience welfare issues during the nursery phase. This pilot study aimed to test a protocol for identifying the main welfare issues in suckling piglets and to investigate relationships among animal-based indicators and management conditions ...
Marika Vitali   +6 more
doaj   +1 more source

Effect of previous handling experiences on responses of dairy calves to routine husbandry procedures [PDF]

open access: yes, 2013
The nature of human–animal interactions is an important factor contributing to animal welfare and productivity. Reducing stress during routine husbandry procedures is likely to improve animal welfare.
McLeay, Lance M.   +5 more
core   +2 more sources

Interactions of Sea Anemone Toxins with Insect Sodium Channel—Insights from Electrophysiology and Molecular Docking Studies

open access: yesMolecules, 2021
Animal venoms are considered as a promising source of new drugs. Sea anemones release polypeptides that affect electrical activity of neurons of their prey.
Beata Niklas   +5 more
semanticscholar   +1 more source

Home - About - Disclaimer - Privacy