Results 81 to 90 of about 2,926,121 (366)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Costunolide and dehydrocostus lactone alleviate ulcerative colitis via regulating TLR4, NF-κB and PI3K expression

Scientific Reports
In this study, we aimed to study the mechanism of costunolide (COS) and dehydrocostus lactone (DEH) in the treatment of ulcerative colitis (UC) based on network pharmacology, molecular docking and animal experiments.
Songting Liang, Chu Chen, Ruoshi Li, Guihua Jiang, Leilei Du   +4 more
doaj   +1 more source

Using network pharmacology and molecular docking technology, proteomics and experiments were used to verify the effect of Yigu decoction (YGD) on the expression of key genes in osteoporotic mice

Annals of Medicine
Background Yigu decoction (YGD) is a traditional Chinese medicine prescription for the treatment of osteoporosis, although many clinical studies have confirmed its anti-OP effect, but the specific mechanism is still not completely clear.Methods In this ...
Kun Yan, Rui-Kun Zhang, Jia-Xin Wang, Hai-Feng Chen, Yang Zhang, Feng Cheng, Yi Jiang, Min Wang, Ziqi Wu, Xiao-Gang Chen, Zhi-Neng Chen, Gui-Jin Li, Xin-Miao Yao   +12 more
doaj   +1 more source

Integrating network pharmacological and experimental models to investigate the therapeutic effects of baicalein in glaucoma

Chinese Medicine, 2021
Background Traditional Chinese medicine (TCM) has a long history of treating glaucoma with remarkable effects, but there is no clear conclusion on its mechanism.
Jiawei Yang, Mingxu Zhang, Qiuyi Song, Siqi Li, Xiulan Zhao, Liping Kan, Siquan Zhu   +6 more
doaj   +1 more source

Integrating network pharmacology and animal experimental validation to investigate the action mechanism of oleanolic acid in obesity

Journal of Translational Medicine
Background Obesity, a condition associated with the development of widespread cardiovascular disease, metabolic disorders, and other health complications, has emerged as a significant global health issue.
Tianfeng Liu, Jiliang Wang, Ying Tong, Lele Wu, Ying Xie, Ping He, Shujue Lin, Xuguang Hu   +7 more
semanticscholar   +1 more source

Salivary miRNAs are potential biomarkers for the accurate and precise identification of inflammatory response after tail docking and castration in piglets.

Journal of Animal Science, 2020
The present study aimed to investigate whether acute pain associated with castration and tail docking of male piglets may modulate the expression of salivary miRNAs and to explore their potential use as biomarkers. Thirty-six healthy piglets (Hermitage x
C. Lecchi, V. Zamarian, C. Gini, C. Avanzini, A. Polloni, Sara Rota Nodari, F. Ceciliani   +6 more
semanticscholar   +1 more source

Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix. [PDF]

, 2019
The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, which inhibits cell-cycle progression until its inactivation by ...
Cristea, Sandra, Kõivomägi, Mardo, Rubin, Seth M, Sage, Julien, Skotheim, Jan M, Tambo, Carrie S, Topacio, Benjamin R, Xie, Shicong, Zatulovskiy, Evgeny   +8 more
core  

A review about lycopene-induced nuclear hormone receptor signalling in inflammation and lipid metabolism via still unknown endogenous apo-10´-lycopenoids [PDF]

, 2016
Lycopene is the red pigment in tomatoes and tomato products and is an important dietary carotenoid found in the human organism. Lycopene-isomers, oxidative lycopene metabolites and apo-lycopenoids are found in the food matrix.
Aydemir, Gamze, Caris-Veyrat, Catherine, Garcia, Ada L., Lucas, Renata, Reynaud, Eric, Rühl, Ralph   +5 more
core   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Do Deep Learning Models Really Outperform Traditional Approaches in Molecular Docking? [PDF]

arXiv, 2023
Molecular docking, given a ligand molecule and a ligand binding site (called ``pocket'') on a protein, predicting the binding mode of the protein-ligand complex, is a widely used technique in drug design. Many deep learning models have been developed for molecular docking, while most existing deep learning models perform docking on the whole protein ...
arxiv