Results 81 to 90 of about 135,313 (306)

Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase

FEBS Open Bio, 2021
Bacterial phospholipases and sphingomyelinases are lipolytic esterases that are structurally and evolutionarily heterogeneous. These enzymes play crucial roles as virulence factors in several human and animal infectious diseases.
Laura Monturiol‐Gross, Fabian Villalta‐Romero, Marietta Flores‐Díaz, Alberto Alape‐Girón   +3 more
doaj   +1 more source

Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity. [PDF]

, 2007
he important role of cyclooxygenase-2 (COX-2) in the pathogenesis of inflammation and side effect limitations of current COX-2 inhibitor drugs illustrates a need for the design of new compounds based on alternative structural templates.
ANZELLOTTI P, ANZINI M., BIAVA M, BOTTA M, CAPPELLI A, FORLI S, GHELARDINI C, MAKOVEC F, MANETTI, F, PATRIGNANI P, PERGOLA, CARLO, POCE G, PORRETTA GC, ROSSI, ANTONIETTA, ROVINI M, SAUTEBIN, LIDIA, SUPINO S, VIVOLI E   +17 more
core   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

The effect of local or general anesthesia on the physiology and behavior of tail docked pigs

Animal, 2011
Tail docking of pigs is a routine procedure on farms to help control tail-biting behavior; however, docking can cause pain. The objective of this research was to evaluate the effect of local or general anesthesia on the physiology (experiment 1) and ...
M.A. Sutherland, B.L. Davis, J.J. McGlone   +2 more
doaj   +1 more source

A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function [PDF]

, 2019
Connexin hemichannels, which are plasma membrane hexameric channels (connexons) composed of connexin protein protomers, have been implicated in a host of physiological processes and pathological conditions. A number of single point pathological mutations
Buratto, Damiano, Carrer, Andrea, Chiani, Francesco, Kuang, Yuanyuan, Lerner, Richard A, Mammano, Fabio, Nardin, Chiara, Paludetti, Gaetano, Salvatore, Anna Maria, Xu, Liang, Yang, Guang, Ziraldo, Gaia, Zonta, Francesco   +12 more
core   +1 more source

Interfacial Bioengineering of Dynamic Networks Hybrid Hydrogel for Programmed Intervention in Oral Precancerous Epithelial States

Advanced Healthcare Materials, EarlyView.
This study develops a dual‐bioinspired hydrogel, MSA@PGel (macrophage membrane‐coated and salvianolic acid B/5‐aminolevulinic acid co‐loaded liposomes embedded in a polydopamine‐based gel), that integrates macrophage membrane‐mediated active targeting and mussel‐inspired wet adhesion for programmed intervention in oral precancerous lesions.
Xiaoxian Zhao, Ao Zheng, Zhengyan Zhao, Qilin Li, Tianhao Wan, Tanjun Deng, Ying Zhang, Lingyan Cao, Lan Wu   +8 more
wiley   +1 more source

ffect of castration and docking of lambs on maintenance behaviour and cortisol level

Journal of Veterinary Medical Research, 2018
Thirty apparently healthy lambs with average weight and age of 5.8±0.5 kg and 15±1.6 days respectively were chosen in Sids Agricultural Research Station belonging to Animal Production Research Institute in Beni-Suef governorate to investigate the effect ...
H.H. Emeash, A.S. Mostafa, N. M. Abdel-Azem   +2 more
doaj  

Coronavirus disease 2019 (COVID-19) in domestic animals and wildlife: advances and prospects in the development of animal models for vaccine and therapeutic research

Human Vaccines & Immunotherapeutics, 2020
SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), is suspected to have been first contracted via animal-human interactions; it has further spread across the world by efficient human-to-human transmission.
Khan Sharun, Ruchi Tiwari, Shailesh Kumar Patel, Kumaragurubaran Karthik, Mohd Iqbal Yatoo, Yashpal S. Malik, Karam Pal Singh, Parmod Kumar Panwar, Harapan Harapan, Raj Kumar Singh, Kuldeep Dhama   +10 more
doaj   +1 more source

ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. [PDF]

, 2016
The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC). However, the determinants of AR overexpression in CRPC are poorly defined.
Borowsky, Alexander D, Cai, Demin, Chen, Hong-Wu, Duan, Zhijian, Evans, Christopher P, Evans, Ronald M, Gao, Allen C, Kung, Hsing-Jien, Lam, Kit S, Louie, Maggie C, Wang, Junjian, Xiang, Qiuping, Xu, Jianzhen, Xu, Yong, Xue, Xiaoqian, Yang, Joy C, Zhang, Yan, Zou, June X   +17 more
core   +2 more sources

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source