Results 91 to 100 of about 1,113,334 (249)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Efficient Classification of Long Documents Using Transformers [PDF]

open access: green, 2022
Hyunji Hayley Park   +2 more
openalex   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Razón moral, razón política, razón ficcional: en torno a El monarca de las sombras (2017) de Javier Cercas y la ficción de archivo

open access: yesCuadernos LIRICO
The novel by Spanish writer Javier Cercas, The Monarch of Shadows (2017), closes a cycle of archival fiction inaugurated by his most famous work, Soldiers of Salamis (2001).
Yael Natalia Tejero Yosovitch
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Fundamentos da organização da informação frente à produção de documentos

open access: yesTransinformação
Explora a noção de organização da informação documentária na perspectiva da produção de documentos. Compreende a produção de documentos como processo de elaboração de registros de informação que dão acesso às unidades de conhecimento, e não como produção
Cristina Dotta Ortega
doaj  

A Model Driven Framework for Collaborative and Dynamic Design and Implementation of NoSQL-Oriented Data warehouses

open access: yesJordanian Journal of Computers and Information Technology
Nowadays, modernizing the data warehouse ecosystem is a key challenge in decision support systems. This modernization is crucial for ensuring scalability and meeting evolving business requirements, especially with the advent of big data.
Khadija Letrache, Mohammed Ramdani
doaj   +1 more source

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