Results 51 to 60 of about 506,073 (323)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Perfumed historic buildings: Issues of authenticity [PDF]
Spatium, 2016 Contemporary historical preservation practice includes olfactory preservation as an experimental method of architectural preservation. The implementation of manufactured scents in historic buildings raises important issues of authenticity.
Tošić Jovana
doaj +1 more source
Privacy-Preserving Multi-Document Summarization
, 2015 State-of-the-art extractive multi-document summarization systems are usually designed without any concern about privacy issues, meaning that all documents are open to third parties. In this paper we propose a privacy-preserving approach to multi-document summarization.
Marujo, Luís +8 more
openaire +2 more sources
RUANG NORMAL DALAM TOPOLOGI [PDF]
, 1985 Dalam tulisan ini later belakang pembicaraan adalah ruang topologi . Pada ruang topologi akan di normal ruang normal ini akan dikaitkan dengan misalnya : regular ,pa sebagainya . definisi-definisi yang berkaitan dengan ruang topologi ,
PRIHANTORO , EDIE
core
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
O documento arquivístico digital enquanto fonte de pesquisa
Perspectivas em Ciência da Informação, 2017 Resumo Este estudo realiza uma reflexão sobre as transformações do documento arquivístico, contextualizando-o como fonte de pesquisa. Discorre-se sobre questões como a evolução das tecnologias da informação, suas consequentes vulnerabilidades e a ...
Henrique Machado dos Santos +1 more
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Liinc em Revista, 2015 RESUMO Os constantes avanços das tecnologias da informação ocasionaram mudanças no que tange à gênese do documento arquivístico, considerado objeto de estudo da arquivologia.
Daniel Flores +1 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source