Results 71 to 80 of about 394,933 (283)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Mapping research trends in shared decision-making for type 2 diabetes mellitus: a bibliometric study
Frontiers in Health ServicesBackgroundType 2 Diabetes Mellitus (T2DM) requires continuous and complex decision-making, including treatment initiation, therapy intensification, and lifestyle considerations.
Carla Salgado-Castillo +6 more
doaj +1 more source
Le documentaire pour la jeunesse en Pologne avant et après 1989 : terminologie et critique
Strenae, 2017 The goal of this article is to shed light on the place of documentaries within children’s book criticism in Poland from 1945 to present day. The article will start with the question of terminology and then proceed to past and current states of research ...
Agnieszka Wandel
doaj +1 more source
Rechtsgeschichte - Legal History, 2021 This article explains how, from 2012 to 2015, the authors conceived, shot and edited the film »Un Tribunal para la Constitución«, a documentary about the first years of the Constitutional Court of Spain.
Miguel Beltrán, Daniel Sarmiento
doaj +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Agnès Varda: filming the Black Panthers's Struggle
L'Ordinaire des Amériques, 2014 Agnès Varda directed two documentaries on the Black Panthers in 1968. Huey captures the militant atmosphere of the “free Huey” campaign whereas Black Panthers focuses on its local impact on the African American community of Oakland.
Delphine Letort
doaj +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source