Results 71 to 80 of about 2,502,152 (334)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Contemporary Political Discourse in Digital Games: A Systematic Approach

Media and Communication
This study reviews existing literature on how video games are being used to convey contemporary political discourse. Digital games, as meaningful cultural artifacts, have become a communication medium in their own right. They can serve as social mirrors,
Jenniffer Soto de la Cruz, Sara Cortés Gómez, Pilar Lacasa   +2 more
doaj   +1 more source

Drive program documentation [PDF]

The program description and user's guide for the Downlist Requirement Integrated Verification and Evaluation (DRIVE) program is provided.
Graham, S.
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Collaborative weighting in federated graph neural networks for disease classification with the human-in-the-loop

Scientific Reports
The authors introduce a novel framework that integrates federated learning with Graph Neural Networks (GNNs) to classify diseases, incorporating Human-in-the-Loop methodologies. This advanced framework innovatively employs collaborative voting mechanisms
Christian Hausleitner, Heimo Mueller, Andreas Holzinger, Bastian Pfeifer   +3 more
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

A First-Person Theory of Documentation [PDF]

, 2019
Purpose To first articulate and then illustrate a descriptive theoretical model of documentation (i.e., document creation) suitable for analysis of the experiential, first-person perspective.
Gorichanaz, Tim
core  

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Sztuka i Dokumentacja nr 20 - CAŁY / Art and Documentation no. 20 – ALL [PDF]

Sztuka i Dokumentacja, 2019
Art and Documentation
doaj   +1 more source

Active Learning and ICT in Upper Secondary School: an Exploratory Case Study on Student Engagement by Debating

EAI Endorsed Transactions on e-Learning, 2017
The paper outlines the first phase of a three-year research activity on active learning in the core curriculum subject, intended as a possible solution to student disengagement in secondary schools.
S. Panzavolta, C. Laici
doaj   +1 more source