Results 121 to 130 of about 612,079 (291)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Working paper on documentation of projects in economic and social development

open access: yes, 1972
DraftOutlines a concept, a logical design, data structure, and a still incomplete vocabulary of an inter-organizational information system on project ...
Inter-Organization Board for Information Systems and Related Activities
core   +1 more source

Documentation as part of substance use rehabilitation: how workers account for the significance of documentation during interviews [PDF]

open access: yes
Purpose: The focus of this article is in documentation in substance abuse inpatient rehabilitation. Our article scrutinizes how workers give accounts of the documentation in the inpatient substance abuse rehabilitation unit and what kind of client ...
Günther, Kirsi   +2 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

The need for information literacy skills among users of European Union information [PDF]

open access: yes, 2008
The aim of this paper is the assessment of information literacy skills related to European topics, among a group of 234 users of 55 European Documentation Centres (EDCs), from 21 European Union Member- States.
Terra, Ana Lúcia
core   +1 more source

Considering Documents in Lifelog Information Retrieval

open access: yesProceedings of the 2018 ACM on International Conference on Multimedia Retrieval, 2018
Lifelogging is a research topic that is receiving increasing attention and although lifelog research has progressed in recent years, the concept of what represents a document in lifelog retrieval has not yet been sufficiently explored. Hence, the generation of multimodal lifelog documents is a fundamental concept that must be addressed.
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

A Survey on Characteristics of Core Latin Journals in Scientific Output of Faculty Members of Tehran University in Accordance to ISI Citations and JCR Impact Factor During 1990-2009

open access: yesIranian Journal of Information Processing & Management, 2010
The present study intends to investigate characteristics of core Latin journals in scientific output of faculty members of Tehran University (Faculties of Humanities, Psychology and Education, Social Science and Art) indexed in A&HCI, SSCI (Thomson ...
Fatemeh Jafari, Fatemeh Fahimnia
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

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