Results 101 to 110 of about 597,454 (292)

SelMa - Self-guided Learning in Teaching Mathematics

Informatics in Education, 2004
In the project ``Self-guided Learning in Teaching Mathematics - SEC II'' (SelMa), five authoring schools are working out scenarios, media and materials for phases of self-guided learning, which will be tested systematically by 10 trial schools with ...
Wolfgang WEBER
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

WEB-BASED DIGITAL DOCUMENT GOVERNANCE SYSTEM FOR OPTIMIZING MULTI-AGENCY COMPLIANCE MONITORING: AN EMPIRICAL STUDY AT TEGAL CITY PPID

Pilar Nusa Mandiri
Information and documentation management at the Public Information and Documentation Management Office of Tegal City faces operational challenges due to reliance on manual mechanisms for collecting files from 73 Regional Government Agencies.
Rahmat Afandi, Nurmalasari Nurmalasari
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Metadata interoperability in public sector information [PDF]

, 2009
Over recent years, there has been a worldwide growing need for interoperability among the systems that manage and reuse Public Sector Information.
Soulikias, Vasilis, Papatheodorou, Christos, Bountouri, Lina, Stratis, Mathios   +3 more
core   +1 more source

Che cos’è una biblioteca ‘normale’?

AIB Studi, 2022
Giuseppe Vitiello
doaj   +1 more source

ANTROPONYMS AS AN OBJECT OF LINGUO-CRIMINALISTIC EXPERTIZE

Неофилология, 2016
The notion linguistic expertise is understood. Linguistic research is often hidden in this notion. It is proved that it is the example of onomastic research diversification. It is established that Russian citizens have difficult problems with equal legal
Mikhail Viktorovich Gorbanevskiy, Vladimir Olegovich Maksimov   +1 more
doaj  

Open Access Repositories: A Global Perspective with an Emphasis on Asia

Cybrarians Journal, 2014
 This research examines the growth and development of open access repositories that have registered in OpenDOAR database. The study reveals many aspects of open access repositories and attempts to provide a clear sign of their overall development.
Zahid Wani, Sumeer Gul, Javeed Rah, Achouri Nadhira, Mohammed Nabti   +4 more
doaj   +1 more source