Results 31 to 40 of about 2,420 (113)

Effect of phenylephrine and prazosin on the somatostatinergic system in the rat frontoparietal cortex [PDF]

, 1994
Somatostatin (SS) and noradrenaline (NA) are distributed in the rat cerebral cortex, and seizure activity is one of the aspects of behavior affected by both neurotransmitters.
Arilla Ferreiro, Eduardo, López Sañudo, Susana, Martín Espinosa, Ángela, Rodríguez Martín, Eulalia   +3 more
core   +3 more sources

5-HT2A receptor signalling through phospholipase D1 associated with its C-terminal tail [PDF]

, 2011
The 5-HT2AR (5-hydroxytryptamine-2A receptor) is a GPCR (G-protein-coupled receptor) that is implicated in the actions of hallucinogens and represents a major target of atypical antipsychotic agents.
Abbas, Banes, Berg, Bhattacharya, Cockcroft, Dean, Derek N. Robertson, Du, Du, Du, Eve M. Lutz, Fensome, Garrido, Gonzalez-Maeso, Gooz, Guillet-Deniau, Hammond, Hanke, Heuss, Hoyer, Ichikawa, Johnson, Johnson-Farley, Klein, Koch, Kurrasch-Orbaugh, Kurrasch-Orbaugh, Lavieri, Lee, Lehmann, Liting Sun, Louise Dickson, McCulloch, Melanie S. Johnson, Mitchell, Mitchell, Mitchell, Moya, Pamela J. Holland, Pehek, Perez-Mansilla, Quinn, Rajagopal, Rankovic, Rizzo, Roberta Rosie, Robertson, Rory Mitchell, Roth, Schmid, Schmidt, Scott, Shome, Sue Fleetwood-Walker, Sun, Tian, Yu, Zeniou-Meyer, Zoë Barclay   +58 more
core   +3 more sources

Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity [PDF]

, 2018
Obesity leading to hyperlipidaemia and atherosclerosis is recognised to induce morphological and metabolic changes in many tissues. However, both hyperlipidaemia and atherosclerosis can occur in the absence of obesity. The impact of the latter scenario
Aburima, A., Beltran-Alvarez, P., Crispi, V., Giallourou, N., Kearney, M. T., Matsakas, Antonios, Mougios, V., Patel, Ketan, Sfyri, P. P., Swann, Jonathan R., Tzimou, A., Yuldasheva, N. Y.   +11 more
core   +2 more sources

Deciphering neuronal deficit and protein profile changes in human brain organoids from patients with creatine transporter deficiency [PDF]

, 2023
Creatine transporter deficiency (CTD) is an X-linked disease caused by mutations in the SLC6A8 gene. The impaired creatine uptake in the brain results in intellectual disability, behavioral disorders, language delay, and seizures.
Apati, A, Armengaud, J, Broca-Brisson, L, Costa, N, Disdier, C, Gaston-Breton, R, Guyot, AC, Hamoudi, RA, Harati, R, Mabondzo, A, Madrange, L, Maïza, A, Mozner, O, Sarkadi, B, Skelton, MR, Yates, F   +15 more
core  

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 69-106, January/February 2026.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Safety Evaluation of Serendipity Berry Sweet Protein From Komagataella phaffii

Journal of Applied Toxicology, Volume 45, Issue 8, Page 1455-1475, August 2025.
ABSTRACT Serendipity Berry Sweet Protein (sweelin) is a novel hyper‐sweet thermophilic protein designed using Artificial Intelligence Computational Protein Design (AI‐CPD) to improve the stability and sensory profile of the protein found in serendipity berry (Dioscoreophyllum cumminsii).
Yael Lifshitz, Shira Paz, Rotem Saban, Inbar Zuker, Hagay Shmuely, Katy Gorshkov, Jwar Meetro, Shahrzad Tafazoli, Trung Vo, Gabriela Amiram, Carmit Shani Levi, Uri Lesmes, Ilan Samish   +12 more
wiley   +1 more source

Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells [PDF]

, 2014
Akt, protein kinase B; ARE, antioxidant response element; Erk, extracellular signal-regulated kinase; CBP, CREB-binding protein; CREB, cAMP response-element (CRE) binding protein; CDK, cyclin-dependent kinase; DHE, dihydroethidium; Drp1, dynamin-related ...
Oliveira, Ana M., Oliveira, Catarina R., Rego, A. Cristina, Ribeiro, Márcio, Rosenstock, Tatiana R.   +4 more
core   +1 more source

Biochemical and Biological Profiles of Bangladeshi Russell’s Viper Snake Venom and Neutralizing Efficacy by Indian VINS Polyvalent Antivenom

Journal of Toxicology, Volume 2025, Issue 1, 2025.
The Russell’s viper (Daboia russelii) has recently become a significant threat to human life in Bangladesh. Given its wide distribution across South Asia, the venom characteristics and lethality can vary by region with different toxicological properties.
Rubait Hasan, Hasanuzzaman Manik, Md Ataur Rahman, Jamiatul Husna Shathi, Md Tariqul Islam, Mohammad Shahangir Biswas, Kazi Md. Faisal Hoque, Phuping Sucharitakul   +7 more
wiley   +1 more source

Influence of Age on Rat Bone-Marrow Mesenchymal Stem Cells Potential [PDF]

, 2015
[Abstract] Mesenchymal stem cells promising role in cell-based therapies and tissue engineering appears to be limited due to a decline of their regenerative potential with increasing donor age.
Arufe, M.C., De-Toro, Javier, Fafián Labora, Juan Antonio, Fernández-Pernas, Pablo, Fuentes Boquete, Isaac Manuel, Mateos, Jesús, Oreiro, Natividad, Sangiao-Alvarellos, Susana   +7 more
core   +2 more sources

Epithelial barrier dysfunction and associated diseases in companion animals: Differences and similarities between humans and animals and research needs

Allergy, Volume 79, Issue 12, Page 3238-3268, December 2024.
Abstract Since the 1960s, more than 350,000 new chemicals have been introduced into the lives of humans and domestic animals. Many of them have become part of modern life and some are affecting nature as pollutants. Yet, our comprehension of their potential health risks for both humans and animals remains partial.
Sena Ardicli, Ozge Ardicli, Duygu Yazici, Yagiz Pat, Huseyn Babayev, Peng Xiong, Can Zeyneloglu, Asuncion Garcia‐Sanchez, Li‐Li Shi, Oliva Giannelli Viscardi, Stephen Skolnick, Ismail Ogulur, Raja Dhir, Marek Jutel, Ioana Agache, Jozef Janda, Isabella Pali‐Schöll, Kari C. Nadeau, Mubeccel Akdis, Cezmi A. Akdis   +19 more
wiley   +1 more source