Results 1 to 10 of about 1,127 (131)
United European Gastroenterology Journal, Volume 13, Issue 5, Page 685-696, June 2025.ABSTRACT Background The Montreal classification has been widely used in Crohn's disease since 2005 to categorize patients by the age of onset (A), disease location (L), behavior (B), and upper gastrointestinal tract and perianal involvement. With evolving management paradigms in Crohn's disease, we aimed to assess the performance of gastroenterologists
Offir Ukashi +44 more
wiley +1 more source
Alzheimer's disease traits in Parkinson's disease without α‐synuclein seeding
Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.Abstract INTRODUCTION The α‐synuclein (αSyn) seed amplification assay (αSyn‐SAA) is an accurate tool to detect αSyn seeds in patients with Parkinson's disease (PD). However, a minority of clinically diagnosed PD patients are negative for αSyn. METHODS The αSyn‐SAA was performed in cerebrospinal fluid (CSF) of individuals with PD (n = 93), multiple ...
Bárbara Fernandes Gomes +10 more
wiley +1 more source
Nefropatia isquêmica Ischemic nephropathy
Jornal Vascular Brasileiro, 2012 A doença renal isquêmica ou nefropatia isquêmica relacionada à doença renovascular pode evoluir de forma rápida e progressiva para a insuficiência renal crônica.
Marcelo Salame +7 more
doaj +1 more source
Plasma p‐tau212 as a biomarker of sporadic and Down syndrome Alzheimer's disease
Alzheimer's &Dementia, Volume 21, Issue 4, April 2025.Abstract BACKGROUND All individuals with Down syndrome (DS) will develop full‐blown Alzheimer´s disease (AD) pathology by age 40. Several genes encoded in chromosome 21, including dual‐specificity tyrosine phosphorylation‐regulated kinase 1A (DYRK1A), have been proven to contribute to the pathology. Phosphorylation of tau at threonine‐212 (p‐tau212) is
Przemysław R. Kac +18 more
wiley +1 more source
Data‐driven evaluation of suitable immunogens for improved antibody selection
Protein Science, Volume 34, Issue 4, April 2025.Abstract Antibodies are indispensable in laboratory and clinical applications due to their high specificity and affinity for protein antigens. However, selecting the right protein fragments as immunogens for antibody production remains challenging. Leveraging the Human Protein Atlas, this study systematically evaluates immunogen properties aiming to ...
Katharina Waury +5 more
wiley +1 more source
Serum Neutrophil Biomarkers to Predict Crohn's Disease Progression and Infliximab Treatment Outcomes
United European Gastroenterology Journal, Volume 13, Issue 2, Page 229-239, March 2025.ABSTRACT Background and aims Predicting the treatment outcomes of biological therapies is an unmet need in Crohn's Disease. In this study, we explored the potential of serum neutrophil‐related biomarkers to predict infliximab therapeutic results and disease progression in Crohn's Disease patients, over a 2‐year period, in a real‐world setting.
D. Magalhaes +41 more
wiley +1 more source
Machine learning prediction of tau‐PET in Alzheimer's disease using plasma, MRI, and clinical data
Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.Abstract INTRODUCTION Tau positron emission tomography (PET) is a reliable neuroimaging technique for assessing regional load of tau pathology in the brain, but its routine clinical use is limited by cost and accessibility barriers. METHODS We thoroughly investigated the ability of various machine learning models to predict clinically useful tau‐PET ...
Linda Karlsson +19 more
wiley +1 more source
Um caso de recuperação da função renal na síndrome hemolítico-urêmica tratada com eculizumab
Brazilian Journal of Nephrology, 2016 Resumo A síndrome hemolítico-urêmica atípica (SHUa) é uma doença grave, pouco prevalente, com acometimento em qualquer idade e apresentação esporádica ou familiar. A SHUa é causada por uma ativação descontrolada do sistema complemento. A plasmaférese foi
João Samuel de Holanda Farias +6 more
doaj +1 more source
Síndrome Hemolítico-Urêmica na infância
Brazilian Journal of Nephrology, 2014 O grupo de doenças que podem manifestar-se com MAT podem apresentar superposição clínica, dificultando o diagnóstico diferencial. Entre estas ressaltamos a PTT e SHU, sendo que esta última pode ocorrer pela ação de toxinas, doenças sistêmicas ...
Maria Helena Vaisbich
doaj +1 more source
Cicatrização de anastomoses do cólon esquerdo com doença inflamatória: estudo experimental em ratos
Acta Cirúrgica Brasileira, 2000 Complicações relacionadas com a anastomose são descritas com freqüência nas cirurgias para o tratamento da doença inflamatória do cólon. Para conhecer a interferência da inflamação na cicatrização de anastomoses 40 ratos Wistar são utilizados e divididos
Fernando Hintz Greca +6 more
doaj +1 more source