Results 111 to 120 of about 1,250,382 (359)

Can we continue research in splenectomized dogs? Mycoplasma haemocanis: Old problem - New insight [PDF]

, 2004
We report the appearance of a Mycoplasma haemocanis infection in laboratory dogs, which has been reported previously, yet, never before in Europe. Outbreak of the disease was triggered by a splenectomy intended to prepare the dogs for a hemorrhagic shock
A. Schropp, Benjamin MM, Berent LM, Birkenheuer A, Brinson J, Brodey RS, C. Wojtczyk, Crowell JW, Davies BN, Donovan EF, Dunham CM, E. Thein, F. Meisner, G. Enders, G. Kemming, Gretillat S, H. Kisch-Wedel, Hartwig G, Hoskins JD, J.B. Messick, K. Messmer, K. Packert, Krakowka S, Lester SL, Messick JB, Pryor, S. Muenzing, Seneviratna P, Venable JH, W. Mueller, Walcott WW, West HJ, Wiggers CJ, Withrington PG, Wright IG, Zweifach BW   +35 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Age Is Just a Number: No Impacts of Scat Ageing on Single Nucleotide Polymorphism Genotyping Using a Target Capture Approach

Ecology and Evolution
Recent advances in DNA sequencing and genotyping technologies are rapidly building our capacity to address ecological, evolutionary, and conservation questions for wildlife. However, wildlife genetic research increasingly relies on samples containing low
Alexis L. Levengood, Katrin Hohwieler, Daniel Powell, Romane H. Cristescu   +3 more
doaj   +1 more source

Supporting Families to ‘Make the Most’ of the Relationship Between Their Companion Dogs and Their Children with Autism Spectrum Condition: A Qualitative Exploration of the ‘Family Dog Service’

Behavioral Sciences
Evidence suggests that assistance and therapy dogs can positively impact the mental and physical health of children with autism spectrum condition (ASC) and their families. However, these services are often costly and inaccessible.
Emily Shoesmith, Heidi Stevens, Selina Gibsone, Cari Miles, Hannah Beal, Kelly Jennings, Elena Ratschen   +6 more
doaj   +1 more source

Canine Olfactory Thresholds to Amyl Acetate in a Biomedical Detection Scenario

Frontiers in Veterinary Science, 2019
Dogs' abilities to respond to concentrations of odorant molecules are generally deemed superior to electronic sensors. This sensitivity has been used traditionally in many areas; but is a more recent innovation within the medical field.
Astrid R. Concha, Astrid R. Concha, Claire M. Guest, Rob Harris, Thomas W. Pike, Alexandre Feugier, Helen Zulch, Helen Zulch, Daniel S. Mills   +8 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Exploring the potential role of built environments in wildlife conservation during wildfires

Conservation Science and Practice
As the frequency and severity of wildfires continue to rise, fire refugia could play a critical role in reducing impacts on affected wildlife species.
Katrin Hohwieler, Carmen Piza Roca, Elizabeth Brunton, Michelle Ward, Romane H. Cristescu   +4 more
doaj   +1 more source

Maximising the Potential Benefit of Living with Companion Dogs for Autistic Children and Their Families: A Mixed-Methods Survey of the Impact of a Novel ‘Family Dog Service’

Animals
Background: Assistance dogs can support children with autism by improving emotional regulation and social functioning, but access is limited. The Family Dog Service was developed to help families of autistic children gain similar benefits through ...
Emily Shoesmith, Heidi Stevens, Selina Gibsone, Cari Miles, Hannah Beal, Kelly Jennings, Elena Ratschen   +6 more
doaj   +1 more source

The SCUBA-2 850 $\mu m$ follow-up of WISE-selected, luminous dust-obscured quasars

, 2017
Hot dust-obscured galaxies (Hot DOGs) are a new population recently discovered in the \wise All-Sky survey. Multiwavelength follow-up observations suggest that they are luminous, dust-obscured quasars at high redshift.
Fan, Lulu, Han, Yunkun, Jones, Suzy F., Knudsen, Kirsten K.   +3 more
core   +1 more source