Results 41 to 50 of about 17,845 (225)

Mutations Located outside the Integrase Gene Can Confer Resistance to HIV-1 Integrase Strand Transfer Inhibitors

mBio, 2017
Resistance to the integrase strand transfer inhibitors raltegravir and elvitegravir is often due to well-identified mutations in the integrase gene. However, the situation is less clear for patients who fail dolutegravir treatment.
Isabelle Malet, Frédéric Subra, Charlotte Charpentier, Gilles Collin, Diane Descamps, Vincent Calvez, Anne-Geneviève Marcelin, Olivier Delelis   +7 more
doaj   +1 more source

Prevalence of Emergent Dolutegravir Resistance Mutations in People Living with HIV: A Rapid Scoping Review

Viruses
Background: Dolutegravir (DTG) is a cornerstone of global antiretroviral (ARV) therapy (ART) due to its high efficacy and favorable tolerability. However, limited data exist regarding the risk of emergent integrase strand transfer inhibitor (INSTI) drug ...
Carolyn Chu, Kaiming Tao, V. Kouamou, Ava Avalos, Jake Scott, Philip M Grant, Soo-Yon Rhee, S. McCluskey, Michael R. Jordan, Rebecca L. Morgan, Robert W. Shafer   +10 more
semanticscholar   +1 more source

Case study: New onset of neuropsychiatric symptoms following switching to a dolutegravir regimen

South African Journal of Psychiatry, 2022
Although reports of neuropsychiatric side effects have been reported with efavirenz, these have been limited in comparison with regard to the now recommended dolutegravir regimens.
Ahmed Badat, Karishma Lowton
doaj   +1 more source

Metabolic implications and safety of dolutegravir use in pregnancy [PDF]

, 2023
Dolutegravir is recommended for all people living with HIV because of its efficacy, high barrier to resistance, favourable safety and tolerability profile, and affordability. Dolutegravir has the highest rates of viral suppression in pregnancy, therefore
Blanco, Camille, Copp, Andrew J, Serghides, Lena, Dontsova, Valeriya, Mohan, Haneesha, Jao, Jennifer, Greene, Nicholas DE, Zash, Rebecca   +7 more
core  

dolutegravir model program.sas

, 2018
model program for dolutegravir ...
Andrew Phillips (591955)
core   +1 more source

Dolutegravir/Lamivudine Is Noninferior to Continuing Dolutegravir- and Non-Dolutegravir-Based Triple-Drug Antiretroviral Therapy in Virologically Suppressed People With Human Immunodeficiency Virus:DUALING Prospective Nationwide Matched Cohort Study [PDF]

BACKGROUND: Confirming the efficacy of dolutegravir/lamivudine in clinical practice solidifies recommendations on its use.METHODS: Prospective cohort study (DUALING) in 24 human immunodeficiency virus (HIV) treatment centers in the Netherlands.
Kootstra, Gert Jan, van Welzen, Berend J, Nellen, Jeannine F., Rijnders, Bart J.A., van den Berk, Guido E.L., Ammerlaan, Heidi S.M., van den Berk, Guido E L, Jordans, Carlijn C E, Vasylyev, Marta, Rijnders, Bart J A, Roukens, Anna H E, den Hollander, Jan G, Lowe, Selwyn H, Delsing, Corine E., van Lelyveld, Steven F L, Groeneveld, Paul H P, Jordans, Carlijn C.E., Leyten, Eliane M.S., Kootstra, Gert-Jan, Soetekouw, Robin, Rijnders, Bart J.A.; id_orcid, van den Berge, Marcel, van Kasteren, Marjo E.E., van der Valk, Marc, Brouwer, Annemarie E, Ammerlaan, Heidi S M, van Kasteren, Marjo E E, Claassen, Mark A.A., Hassing, Robert Jan, van Welzen, Berend J., Delsing, Corine E, Wit, Ferdinand W N M, Wit, Ferdinand W.N.M., Claassen, Mark A A, Hassing, Robert-Jan, den Hollander, Jan G., Bierman, Wouter F W, Lowe, Selwyn H., Leyten, Eliane M S, van Lelyveld, Steven F.L., Rokx, Casper, Bierman, Wouter F.W., Roukens, Anna H.E., Groeneveld, Paul H.P., Brouwer, Annemarie E., Nellen, Jeannine F, Rokx, Casper; id_orcid, Richel, Olivier   +47 more
core   +3 more sources

Mechanistic Modeling of the Drug‐Drug Interaction Between Efavirenz and Dolutegravir: Is This Interaction Clinically Relevant When Switching From Efavirenz to Dolutegravir During Pregnancy?

, 2023
Following the 2021 World Health Organization\u27s updated recommendations on the management of HIV infection, millions of people living with HIV are currently switched from efavirenz-based antiretroviral therapy to dolutegravir-based antiretroviral ...
Rakhmanina, Natella, Dallmann, André, Ahmadzia, Homa K, André Dallmann, John van den Anker, van den Anker, John, Homa K. Ahmadzia, Natella Rakhmanina   +7 more
core   +1 more source

Palladacarboxamide Capping Reagents for Carbon Isotope Labeling and Pharmaceutical Diversification

Angewandte Chemie International Edition, EarlyView.
Herein, we present a method for carbon isotope labeling of arylamides via the coupling of air‐stable palladium carboxamide complexes and boronic ester/acids. A wide variety of functionalized boronic esters and acids have been coupled with simple palladium carboxamides complexes.
Daniel V. Hoffmann, Anika Schick, Lasse Kjær, Vitus J. Enemærke, Clemens Kaussler, Jens Torp, Pablo Martínez‐Pardo, Charles S. Elmore, Troels Skrydstrup   +8 more
wiley   +1 more source

Dolutegravir based antiretroviral therapy compared to other combined antiretroviral regimens for the treatment of HIV-infected naive patients: A systematic review and meta-analysis.

PLoS ONE, 2019
BackgroundNumerous randomized clinical trials (RCTs) were conducted to evaluate dolutegravir based triple antiretroviral therapy (ART) compared to other triple antiretroviral regimens in naïve patients, and a summary of the available evidence is required
Mario Cruciani, Saverio G Parisi
doaj   +1 more source

Dolutegravir pharmacokinetics in pregnant and postpartum women living with HIV [PDF]

, 2018
OBJECTIVE: To evaluate dolutegravir pharmacokinetics during pregnancy compared with postpartum and in infant washout samples after delivery. DESIGN: Ongoing, nonrandomized, open-label, parallel-group, multicenter phase-IV prospective study of ...
Shelley L. Buschur, Mulligan, Nikki, Smith, Elizabeth, Burchett, Sandra, Mark Mirochnick, Wang, Jiajia, Sandra Burchett, Jiajia Wang, Edward P. Acosta, Nahida Chakhtoura, Acosta, Edward P, Best, Brookie M, Alice Stek, Barr, Emily, Nikki Mulligan, Brookie M. Best, Elizabeth Smith, Emily Barr, Edmund V. Capparelli, Capparelli, Edmund V, Buschur, Shelley L, Chakhtoura, Nahida, Stek, Alice, Mirochnick, Mark   +23 more
core   +1 more source