Results 51 to 60 of about 851,047 (286)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Code generation approaches for parallel geometric multigrid solvers
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2020 Software development for applications in computational science and engineering has become complex in recent years. This is mainly due to the increasing parallelism and heterogeneity in modern computer architectures and to the more realistic physical and ...
Köstler Harald +5 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Cognitive Behaviors Modeling Using UML Profile: Design and Experience
IEEE Access, 2017 To achieve model reuse in combat effectiveness simulation systems development, cognitive decision behaviors are usually implemented using a scripting language, which is separate from the programming language used to implement simulation models. Therefore,
Zhi Zhu +3 more
doaj +1 more source
Usability Evaluation of Domain-Specific Languages [PDF]
2012 Eighth International Conference on the Quality of Information and Communications Technology, 2012 The adoption of Domain-Specific Languages (DSLs) is regarded as an approach to reduce the accidental complexity of software systems development. The availability of sophisticated language workbenches facilitates the development of DSLs making them increasingly more popular.
Barisic, Ankica +2 more
openaire +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Visual Dataflow Language for Educational Robots Programming
Труды Института системного программирования РАН, 2018 Visual domain-specific languages usually have low entry barrier. Sometimes even children can program on such languages by working with visual representations.
G. A. Zimin, D. A. Mordvinov
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
TESMA: Requirements and Design of a Tool for Educational Programs †
Information, 2017 Defining and managing teaching programs at universities or other institutions is a complex task for which there is not much support in terms of methods and tools.
Nicolas Guelfi +2 more
doaj +1 more source