Results 131 to 140 of about 1,741,360 (267)
Ontology as Structure, Domain and Definition
The paper presents a spatio-temporal ontology guided by a particular methodology, in which the semantics is constructed within a spatio-temporal interpretation structure that is built up in three stages. The first, stage stipulates a standard classical model of time and space. This structure forms the grounding for the interpretation. The next stage is
Brandon Bennett, Giulia Sindoni
openaire +2 more sources
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
TRIM56 coiled-coil domain structure provides insights into its E3 ligase functions. [PDF]
Comput Struct Biotechnol J, 2023 Lou X +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Effect of Acoustic Oscillations on Non-Equilibrium State of Magnetic Domain Structure in Cubic Ni2MnGa Single Crystal. [PDF]
Materials (Basel), 2023 Fernández González A +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases. [PDF]
Adv Exp Med Biol, 2022 Tajima S +5 more
europepmc +1 more source
Structure and function of the SH3 domain
Progress in Biophysics and Molecular Biology, 1994 Musacchio, Andrea +2 more
openaire +3 more sources