Results 151 to 160 of about 10,126,895 (308)
Domain structure and cross-linking in a giant adhesin from the Mobiluncus mulieris bacterium. [PDF]
Acta Crystallogr D Struct Biol, 2023 Young PG +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Domain-General Learning Capacities
, 2018 Language is arguably the most complex system acquired by humans. This fact, combined with the tender age at which language is typically learned, suggests that infants must come to the task of language acquisition already possessing the machinery required
Erik Thiessen (3894916) +1 more
core +1 more source
Distinct functions of FASCILIN-LIKE ARABINOGALACTAN PROTEINS relate to domain structure. [PDF]
Plant Physiol, 2023 Ma Y +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
EFFECTS OF MECHANICAL FAULT IN THE ENERGETICALLY ACTIVE WHISKERS
Вестник Кемеровского государственного университета, 2014 The paper considers the results on flexural deformation detected by the authors in whiskers of lead azides and potassium nitrate when exposed to light, electric field and temperature.
F. I. Ivanov, E. V. Isakova
doaj
Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides having a Domain Structure. [PDF]
Angew Chem Int Ed Engl, 2022 Sun L, Chopra P, Boons GJ.
europepmc +1 more source
Structure of a transporter domain emerges
Journal of Biological Chemistry, 2018 Magnesium homeostasis relies on transporters like the CNNM family, but little information on these proteins' structure and regulation limits our understanding of their biology and functions in disease. New characterization of a conserved cytoplasmic domain now confirms the presence of a self-liganded architecture that is indispensable for Mg2+ efflux ...
openaire +3 more sources
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source