Results 171 to 180 of about 10,126,895 (308)
Ontology as Structure, Domain and Definition
The paper presents a spatio-temporal ontology guided by a particular methodology, in which the semantics is constructed within a spatio-temporal interpretation structure that is built up in three stages. The first, stage stipulates a standard classical model of time and space. This structure forms the grounding for the interpretation. The next stage is
Brandon Bennett, Giulia Sindoni
openaire +2 more sources
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
TRIM56 coiled-coil domain structure provides insights into its E3 ligase functions. [PDF]
Comput Struct Biotechnol J, 2023 Lou X +7 more
europepmc +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Effect of Acoustic Oscillations on Non-Equilibrium State of Magnetic Domain Structure in Cubic Ni2MnGa Single Crystal. [PDF]
Materials (Basel), 2023 Fernández González A +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases. [PDF]
Adv Exp Med Biol, 2022 Tajima S +5 more
europepmc +1 more source
Structure and function of the SH3 domain
Progress in Biophysics and Molecular Biology, 1994 Musacchio, Andrea +2 more
openaire +3 more sources