Results 161 to 170 of about 1,741,360 (267)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Collapse of the standard ferromagnetic domain structure in hybrid Co/Molecule bilayers. [PDF]

Nat Commun
Benini M, Shumilin A, Kabanov V, Rakshit RK, Sahoo A, Halder A, Droghetti A, Cugini F, Solzi M, Bisero D, Graziosi P, Riminucci A, Bergenti I, Singh M, Gnoli L, Sanna S, Cinchetti M, Mertelj T, Sanvito S, Dediu VA.   +19 more
europepmc   +1 more source

Validated determination of NRG1 Ig-like domain structure by mass spectrometry coupled with computational modeling. [PDF]

Commun Biol, 2022
Khaje NA, Eletsky A, Biehn SE, Mobley CK, Rogals MJ, Kim Y, Mishra SK, Doerksen RJ, Lindert S, Prestegard JH, Sharp JS.   +10 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

A divergent two-domain structure of the anti-Müllerian hormone prodomain. [PDF]

Proc Natl Acad Sci U S A
Howard JA, Hok L, Cate RL, Sanford NJ, Hart KN, Leach EAE, Bruening AS, Nagykery N, Donahoe PK, Pépin D, Thompson TB.   +10 more
europepmc   +1 more source

Real-Time Observation of Magnetic Domain Structure Changes with Increasing Temperature for Z-Type Hexagonal Ferrite. [PDF]

Materials (Basel), 2022
Kim SD, Park I.
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Imaging of electric-field-induced domain structure in DyMnO 3 nanocrystals. [PDF]

Discov Nano
Najeeb MA, Morrison R, Mokhtar AH, Porter DG, Lichtenberg F, Bombardi A, Newton MC.   +6 more
europepmc   +1 more source

Novel nitrite reductase domain structure suggests a chimeric denitrification repertoire in the phylum Chloroflexi. [PDF]

Microbiologyopen, 2022
Schwartz SL, Momper L, Rangel LT, Magnabosco C, Amend JP, Fournier GP.   +5 more
europepmc   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source