Results 141 to 150 of about 10,126,895 (308)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Domain structure of a Nd60Al10Fe20Co10 bulk metallic glass
, 2001 Magnetic domain structure of Nd60Al10Fe20Co10 bulk metallic glass (BMG) has been studied by using magnetic-force microscopy. In the magnetic-force images it is shown that the exchange-interaction-type magnetic domains with a period of about 360 nm do ...
Wang, WH (reprint author), Chinese Acad Sci, Natl Micrograv Lab, Inst Mech, Beijing 100080, Peoples R China. +6 more
core +1 more source
Pathogenic mutation hotspots in protein kinase domain structure. [PDF]
Protein Sci, 2023 Medvedev KE +3 more
europepmc +1 more source
Domains in Chromatin Structure
Cold Spring Harbor Symposia on Quantitative Biology, 1978 T, Igó-Kemenes, H G, Zachau
openaire +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Evolution of domain structure being the determinant in the mechanical fatigue process of railway wheelset wheel material [PDF]
Transport Problems, 2007 Investigation of fatigue processes on the basis of domain structure imaging makes possible identification of material zones and fatigue degree and will permit the introduction of changes in the wheel construction at the design stage.
Zbigniew H. ŻUREK, Marek SITARZ
doaj
Identification of the Domain Structure Defects of a Radially Magnetized Rubber-Ferritic Conglomerate. [PDF]
Materials (Basel), 2023 Popowska K, Gontarz S, Szulim P.
europepmc +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Modification of potato starch granule structure and morphology in planta by expression of starch binding domain fusion proteins [PDF]
, 2010 Producing starches with altered composition, structure and novel physico-chemical properties in planta by manipulating the enzymes which are involved in starch metabolism or (over)expressing heterologous enzymes has huge advantages such as broadening the
Huang, X.
core