Results 211 to 220 of about 18,832,580 (328)

Heterologous DNA-prime/protein-boost immunization with a monomeric SARS-CoV-2 spike antigen redundantizes the trimeric receptor-binding domain structure to induce neutralizing antibodies in old mice. [PDF]

Front Immunol, 2023
Pflumm D, Seidel A, Klein F, Groß R, Krutzke L, Kochanek S, Kroschel J, Münch J, Stifter K, Schirmbeck R.   +9 more
europepmc   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

ANO5 p.I616F variant drives florid cemento-osseous dysplasia by disrupting transmembrane domain structure. [PDF]

BMC Oral Health
Zhang L, Jin W, Qin Y, Zhang Y, Qian Y, Li J, Liu Y, Shi Y, Xie R, Wang W.   +9 more
europepmc   +1 more source

Novel nitrite reductase domain structure suggests a chimeric denitrification repertoire in the phylum Chloroflexi. [PDF]

Microbiologyopen, 2022
Schwartz SL, Momper L, Rangel LT, Magnabosco C, Amend JP, Fournier GP.   +5 more
europepmc   +1 more source

ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain.

Structure, 2016
Alexander E. Conicella, Gül H. Zerze, J. Mittal, N. Fawzi   +3 more
semanticscholar   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

SARS-CoV-2 beta variant substitutions alter spike glycoprotein receptor binding domain structure and stability. [PDF]

J Biol Chem, 2021
Moss DL, Rappaport J.
europepmc   +2 more sources

Imaging of electric-field-induced domain structure in DyMnO 3 nanocrystals. [PDF]

Discov Nano
Najeeb MA, Morrison R, Mokhtar AH, Porter DG, Lichtenberg F, Bombardi A, Newton MC.   +6 more
europepmc   +1 more source

Domain Structure, Thermal and Mechanical Properties of Polycaprolactone-Based Multiblock Polyurethane-Ureas under Control of Hard and Soft Segment Lengths. [PDF]

Polymers (Basel), 2022
Bugrov AN, Gorshkova YE, Ivan'kova EM, Kopitsa GP, Pavlova AA, Popova EN, Smirnova VE, Smyslov RY, Svetlichnyi VM, Vaganov GV, Vasil'ev BV.   +10 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source