Results 41 to 50 of about 83,143 (263)

Locally optimal unstructured finite element meshes in 3 dimensions [PDF]

open access: yes, 2004
This paper investigates the adaptive finite element solution of a general class of variational problems in three dimensions using a combination of node movement, edge swapping, face swapping and node insertion.
Bänsch   +15 more
core   +1 more source

BS‐RNase tetramers: An example of domain‐swapped oligomers [PDF]

open access: yesFEBS Letters, 1996
In the ribonuclease superfamily, dimericity is a unique feature of bovine seminal RNase (BS‐RNase). In about two‐thirds of native BS‐RNase molecules, the two subunits interchange their N‐terminal tails, thus generating domain‐swapped dimers (MxM), which mostly responsible for enzyme biological activities and allostericity.
Adinolfi, S   +3 more
openaire   +3 more sources

Structural Insights into RNA Dimerization: Motifs, Interfaces and Functions

open access: yesMolecules, 2020
In comparison with the pervasive use of protein dimers and multimers in all domains of life, functional RNA oligomers have so far rarely been observed in nature.
Charles Bou-Nader, Jinwei Zhang
doaj   +1 more source

Multiscale nature of hysteretic phenomena: Application to CoPt-type magnets [PDF]

open access: yes, 2002
We suggest a workable approach for the description of multiscale magnetization reversal phenomena in nanoscale magnets and apply it to CoPt-type alloys. We show that their hysteretic properties are governed by two effects originating at different length ...
B. Zhang   +12 more
core   +3 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Swapping of transmembrane domains in the epithelial calcium channel TRPV6

open access: yesScientific Reports, 2017
Tetrameric ion channels have either swapped or non-swapped arrangements of the S1–S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold.
Appu K. Singh   +2 more
doaj   +1 more source

DNA polymerase hybrids derived from the family-B enzymes of Pyrococcus furiosus and Thermococcus kodakarensis: improving performance in the polymerase chain reaction

open access: yesFrontiers in Microbiology, 2014
The polymerase chain reaction (PCR) is widely applied across the biosciences, with archaeal Family-B DNA polymerases being preferred, due to their high thermostability and fidelity.
Ashraf eElshawadfy   +5 more
doaj   +1 more source

Mobility and asymmetry effects in one-dimensional rock-paper-scissors games

open access: yes, 2010
As the behavior of a system composed of cyclically competing species is strongly influenced by the presence of fluctuations, it is of interest to study cyclic dominance in low dimensions where these effects are the most prominent.
J. Hofbauer   +3 more
core   +1 more source

Domain Swapping in Abiotic Foldamers

open access: yesAngewandte Chemie International Edition
AbstractFoldamer sequences that adopt tertiary helix‐turn‐helix folds mediated by helix‐helix hydrogen bonding in organic solvents have been previously reported. In an attempt to create genuine abiotic quaternary structures, i.e. assemblies of tertiary structures, new sequences were prepared that possess additional hydrogen bond donors at positions ...
Shuhe Wang   +4 more
openaire   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

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