Results 111 to 120 of about 3,729,691 (188)
A Genetic Risk Variant Associated With the Risk of Primary Biliary Cholangitis Is Inherited From Neanderthals
Liver International, Volume 46, Issue 10, October 2026.ABSTRACT Background
Primary Biliary Cholangitis (PBC) is an autoimmune cholangiopathy with polygenic architecture and unknown aetiology. Evidence links Neanderthal‐derived genetic variants to autoimmune conditions; however, their contribution to PBC susceptibility remains unexplored.Alessio Gerussi, Chiara Caime, Harold Wang, Heather J. Cordell, George F. Mells, Richard N. Sandford, David E. Jones, Gideon Hirschfield, Katherine A. Siminovitch, M. Eric Gershwin, Brian D. Juran, Elizabeth J. Atkinson, Angela Cheung, Mariza de Andrade, Aris Baras, Konstantinos N. Lazaridis, Rosanna Asselta, Pietro Invernizzi, Manuela Sironi, Sriram Sankararaman, Canadian‐US PBC Consortium, UK‐PBC Consortium, James J. Fryett, Rebecca Darlay, Steven Flack, Ann Spicer, Victoria L. Mulcahy, Richard Sturgess, Christopher Healey, Andrew Yeoman, Anton Vj Gunasekera, Paul Kooner, Kapil Kapur, V. Sathyanarayana, Yiannis Kallis, Javaid Subhani, Rory Harvey, Roger McCorry, Paul Rooney, David Ramanaden, Richard Evans, Thiriloganathan Mathialahan, Jaber Gasem, Christopher Shorrock, Mahesh Bhalme, Paul Southern, Jeremy A. Tibble, David A. Gorard, Susan Jones, Brijesh Srivastava, Matthew R. Foxton, Carole E. Collins, David Elphick, Mazn Karmo, Francisco Porras‐Perez, Michael Mendall, Tom Yapp, Minesh Patel, Roland Ede, Joanne Sayer, James Jupp, Neil Fisher, Martyn J. Carter, Konrad Koss, Jayshri Shah, Andrzej Piotrowicz, Glyn Scott, Charles Grimley, Ian R. Gooding, Simon Williams, Judith Tidbury, Guan Lim, Kuldeep Cheent, Sass Levi, Dina Mansour, Matilda Beckley, Coral Hollywood, Terry Wong, Richard Marley, John Ramage, Harriet M. Gordon, Jo Ridpath, Theodore Ngatchu, Vijay Paul Bob Grover, Ray G. Shidrawi, George Abouda, L. Corless, Mark Narain, Ian Rees, Ashley Brown, Simon Taylor‐Robinson, Joy Wilkins, Leonie Grellier, Paul Banim, Debasish Das, Michael A. Heneghan, Howard Curtis, Helen C. Matthews, Faiyaz Mohammed, Mark Aldersley, Raj Srirajaskanthan, Giles Walker, Alistair McNair, Amar Sharif, Sambit Sen, George Bird, Martin I. Prince, Geeta Prasad, Paul Kitchen, Adrian Barnardo, Chirag Oza, Nurani N. Sivaramakrishnan, Prakash Gupta, Amir Shah, Chris Dj Evans, Subrata Saha, Katharine Pollock, Peter Bramley, Ashis Mukhopadhya, Stephen T. Barclay, Natasha McDonald, Andrew J. Bathgate, Kelvin Palmer, John F. Dillon, Simon M. Rushbrook, Robert Przemioslo, Chris McDonald, Andrew Millar, Cheh Tai, Stephen Mitchell, Jane Metcalf, Syed Shaukat, Mary Ninkovic, Udi Shmueli, Andrew Davis, Asifabbas Naqvi, Tom Jw Lee, Stephen Ryder, Jane Collier, Howard Klass, Matthew E. Cramp, Nichols Sharer, Richard Aspinall, Deb Ghosh, Andrew C. Douds, Jonathan Booth, Earl Williams, Hyder Hussaini, John Christie, Steven Mann, Douglas Thorburn, Aileen Marshall, Imran Patanwala, Aftab Ala, Julia Maltby, Ray Matthew, Chris Corbett, Sam Vyas, Saket Singhal, Dermot Gleeson, Sharat Misra, Jeff Butterworth, Keith George, Tim Harding, Andrew Douglass, Harriet Mitchison, Simon Panter, Jeremy Shearman, Gary Bray, Michael Roberts, Graham Butcher, Daniel Forton, Zahid Mahmood, Matthew Cowan, Debashis Das, Chin Lye Ch'ng, Mesbah Rahman, Gregory C. A. Whatley, Emma Wesley, Aditya Mandal, Sanjiv Jain, Stephen P. Pereira, Mark Wright, Palak Trivedi, Fiona H. Gordon, Esther Unitt, Altaf Palejwala, Andrew Austin, Vishwaraj Vemala, Allister Grant, Andrew D. Higham, Alison Brind, Ray Mathew, Mark Cox, Subramaniam Ramakrishnan, Alistair King, Simon Whalley, Jocelyn Fraser, S. J. Thomson, Andrew Bell, Voi Shim Wong, Richard Kia, Ian Gee, Richard Keld, Rupert Ransford, James Gotto, Charles Millson, Italian PBC Genetics Study Group, Andrea Affronti, Maurizia Brunetto, Barbara Coco, Giancarlo Spinzi, Gianfranco Elia, Carlo Ferrari, Ana Lleo, Luigi Muratori, Paolo Muratori, Piero Portincasa, Agostino Colli, Savino Bruno, Guido Colloredo, Francesco Azzaroli, Pietro Andreone, MariaConsiglia Bragazzi, Domenico Alvaro, Vincenzo Cardinale, Nora Cazzagon, Annarosa Floreani, Cristina Rigamonti, Floriano Rosina, Marco Carbone, Laura Cristoferi, Marco Festa, Eugenia Nofit, Miki Scaravaglio, Daphne D'Amato, Federica Malinverno, Pietro Lampertico, Francesca Donato, Stefano Fagiuoli, Piero L. Almasio, Edoardo Giannini, Carmela Cursaro, Massimo Colombo, Luca Valenti, Luca Miele, Angelo Andriulli, Grazia A. Niro, Ignazio Grattagliano, Lorenzo Morini, Giovanni Casella, Maria Vinci, Pier Maria Battezzati, Andrea Crosignani, Massimo Zuin, Alberto Mattalia, Vincenza Calvaruso, Silvia Colombo, Antonio Benedetti, Marco Marzioni, Andrea Galli, Fabio Marra, Mirko Tarocchi, Antonio Picciotto, Filomena Morisco, Luca Fabris, Lory Saveria Crocè, Claudio Tiribelli, Pierluigi Toniutto, Mario Strazzabosco +269 morewiley +1 more sourceThe miR167–ARF8 module coordinates stamen–pistil development and fruit set in tomato
New Phytologist, Volume 252, Issue 2, Page 647-665, October 2026.SlMIR167a is the functionally prominent SlMIR167 gene in tomato fruit development. Summary Auxin is an important regulator of reproductive development. The families of the AUXIN RESPONSE FACTOR (ARF) genes, important components of the auxin signal, have expanded in flowering plants.Nave Man, Naama Teboul, Amir Bahu, Moritz Friesch, Alon Israeli, Tzahi Arazi, Bettina Hause, Naomi Ori +7 morewiley +1 more sourceUsing archaeogenomic and computational approaches to unravel the history of local adaptation in crops [PDF]
, 2014 Our understanding of the evolution of domestication has changed radically in the past 10 years, from a relatively simplistic rapid origin scenario to a protracted complex process in which plants adapted to the human environment.Kitchen, James, Smith, Oliver, Ware, R., Allaby, Robin G., Smith, O., Gutaker, Rafał M., Allaby, R. G., Gutaker, R., Clarke, Andrew C., Palmer, Sarah A., Kitchen, J. L., Gutaker, Rafal, Pearson, Neil, Kitchen, James L., Clarke, A. C., Ware, Roselyn, Pearson, N. +16 morecore +1 more sourceTesting the ‘parasite-mediated domestication’ hypothesis: a comparative approach to the wild boar and domestic pig as model species [PDF]
PeerJThe mechanisms underlying the domestication process have already been well explained. Starting with Belyaev’s pioneering experiment on silver foxes, which showed that selection for tameness (reduced fear response, changes in the ‘hypothalamic-pituitary ...Renat Oleinic, Janez Posedi, Relja Beck, Nikica Šprem, Dubravko Škorput, Boštjan Pokorny, Dejan Škorjanc, Maja Prevolnik Povše, Janko Skok +8 moredoaj +2 more sourcesBeyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity
Obesity Reviews, Volume 27, Issue 10, October 2026.ABSTRACT
Excess adiposity is not a recently developed problem but has existed since at least the upper Paleolithic, allowing evolutionary selection pressures to adapt the physiology of the pregnant woman and the feto‐placental unit for maternal and fetal protection.Gernot Desoye, Ursula Hiden, Evelyn Jantscher‐Krenn, Herbert Fluhr, Jonathan C. Wells, Sonja Entringer, Mireille N. M. van Poppel +6 morewiley +1 more sourceData from: Shifts in plant functional strategies over the course of wheat domestication
, 2017 1. Human selection, changes in environmental conditions and management practices drove the phenotypic trajectory of crops during domestication. The characterization of the crop domestication syndrome lies mostly on reproductive characters.Roucou, Agathe, Agathe Roucou, Cyrille Violle, Ecarnot, Martin, Roumet, Pierre, Escarnot, Martin, Florian Fort, Denis Vile, Martin Ecarnot, Vile, Denis, Violle, Cyrille, Fort, Florian, Pierre Roumet +12 morecore +1 more sourceAnterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes
G3: Genes, Genomes, Genetics, 2018 Domesticated species exhibit a suite of behavioral, endocrinological, and morphological changes referred to as “domestication syndrome.” These changes may include a reduction in reactivity of the hypothalamic-pituitary-adrenal (HPA) axis and specifically Jessica P. Hekman, Jennifer L. Johnson, Whitney Edwards, Anastasiya V. Vladimirova, Rimma G. Gulevich, Alexandra L. Ford, Anastasiya V. Kharlamova, Yury Herbeck, Gregory M. Acland, Lori T. Raetzman, Lyudmila N. Trut, Anna V. Kukekova +11 moredoaj +1 more sourceDetermining the Nutritional Potential of Ancient Wheat Species: A Closer Look at Starch and Protein Digestibility, and Phenolic Acid Content
Cereal Chemistry, Volume 103, Issue 5, Page 669-680, September/October 2026.ABSTRACT Background and Objectives
The recent trend towards healthy food choices and sustainable agriculture has revived interest in underutilized wheat species such as emmer, einkorn, and spelt. Given these developments, the objective of the study was to compare the differences in chemical composition and digestibility characteristics among ...Sathsara Deyalage, Sijo Joseph Thandapilly, James Duncan House, Adam Franczyk, Amanda Gomes Almeida Sá, Maneka Malalgoda +5 morewiley +1 more source