Results 71 to 80 of about 255,903 (249)

Loss of ecologically important genetic variation in late generation hybrids reveals links between adaptation and speciation

Evolution Letters, 2020
Adaptation to contrasting environments occurs when advantageous alleles accumulate in each population, but it remains largely unknown whether these same advantageous alleles create genetic incompatibilities that can cause intrinsic reproductive isolation
Greg M. Walter, Thomas J. Richards, Melanie J Wilkinson, Mark W. Blows, J. David Aguirre, Daniel Ortiz‐Barrientos   +5 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Species richness, composition, and dominance of core and climate relicts of African miombo woodlands

Ecosphere
The miombo woodlands, which span about 10% of the African continent, are essential for the ecosystem services they provide. These woodlands are mainly dominated by the genera Julbernardia, Isoberlinia, and Brachystegia.
Brenden Pienaar, Ed T. F. Witkowski, Dave I. Thompson, Justice Muvengwi   +3 more
doaj   +1 more source

Relating 2-rainbow domination to Roman domination

Discussiones Mathematicae Graph Theory, 2017
For a graph $G$, let $ _R(G)$ and $ _{r2}(G)$ denote the Roman domination number of $G$ and the $2$-rainbow domination number of $G$, respectively. It is known that $ _{r2}(G)\leq _R(G)\leq \frac{3}{2} _{r2}(G)$. Fujita and Furuya (Difference between 2-rainbow domination and Roman domination in graphs, Discrete Applied Mathematics 161 (2013) 806 ...
Alvarado José D., Dantas Simone, Rautenbach Dieter   +2 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Hereditary equality of domination and exponential domination

Discussiones Mathematicae Graph Theory, 2018
We characterize a large subclass of the class of those graphs $G$ for which the exponential domination number of $H$ equals the domination number of $H$ for every induced subgraph $H$ of $G$.
Henning Michael A., Jäger Simon, Rautenbach Dieter   +2 more
openaire   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Quantitative Changes and Transformation of the SME Sector after the Shocks of 2022

Мир новой экономики
The aim of the article is to dentify structural changes in the SME sector, indicating positive dynamics and qualitative transformations of the sector during the adaptation of the Russian economy to the shocks of 2022. The methods of the research is based
A. A. Blokhin, K. V. Glukhov
doaj   +1 more source