Results 71 to 80 of about 1,480,823 (289)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

String-dominated cosmology [PDF]

Physical Review D, 1994
If string theory controls physics at the string scale, the dynamics of the early universe before the GUT era will be governed by the low-energy string equations of motion. Studying these equations for FRW spacetimes, we find that depending on the initial conditions when the stringy era starts, and on the time when it ends, there are a wide variety of ...
Goldwirth, Dalia S., Perry, Malcolm J.
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Ranking Multi-Metric Scientific Achievements Using a Concept of Pareto Optimality

Mathematics, 2020
The ranking of multi-metric scientific achievements is a challenging task. For example, the scientific ranking of researchers utilizes two major types of indicators; namely, number of publications and citations.
Shahryar Rahnamayan, Sedigheh Mahdavi, Kalyanmoy Deb, Azam Asilian Bidgoli   +3 more
doaj   +1 more source

The African Independent Apostolic Church's Doctrine under Threat: The Emerging Power of Faith-based Organisations' Interventions and the Johanne Marange Apostolic Church in Zimbabwe [PDF]

Journal for the Study of Religion, 2017
This article analyses the changing and declining influence of the Johanne Marange Apostolic Church's doctrine and belief system over its members' behaviour and conduct.
Julius Musevenzi
doaj   +1 more source

Social Dominance Orientation Connects Prejudicial Human-Human and Human-Animal Relations [PDF]

, 2014
Recent theorizing suggests that biases toward human outgroups may be related to biases toward (non-human) animals, and that individual differences in desire for group dominance and inequality may underlie associations between these biases.
Allen, Bastian, Cara C. MacInnis, Costello, Dhont, Dhont, Gordon Hodson, Herzog, Hodson, Hodson, Hodson, Hu, Hyers, Joy, Kimberly Costello, Kristof Dhont, Kteily, Milfont, Plous, Pratto, Roets, Schafer, Sibley, Sidanius, Sidanius, Wuensch   +25 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Applying abundance/biomass comparison curves to small mammals: a weak tool for detect urbanization-related stress in the assemblages?

Folia Oecologica, 2020
Urbanization is a form of pervasive human-induced disturbance. We tested the effectiveness of Abundance/Biomass Comparisons (ABC) as an approach in detecting stress due to landscape urbanization in large small mammal assemblages obtained from pellets of ...
di Bagno Ermellina, Battisti Corrado, Zullo Francesco, Amori Giovanni   +3 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Anthropogenic Impacts on Bark and Ambrosia Beetle Assemblages in Tropical Montane Forest in Northern Borneo

Insects
Anthropogenic disturbances, such as forest conversion, have a profound impact on species distributions and biodiversity in tropical forests. This study aimed to determine the diversity and distribution of bark and ambrosia beetles (Curculionidae ...
Evahtira Gunggot, Roger A. Beaver, Jonathan Jimmey Lucas, Sandra Geogina George, Anastasia Rasiah, Wilson V. C. Wong, Maria Lourdes T. Lardizabal, Naoto Kamata   +7 more
doaj   +1 more source