Results 81 to 90 of about 1,749,199 (384)

String-dominated cosmology [PDF]

Physical Review D, 1994
If string theory controls physics at the string scale, the dynamics of the early universe before the GUT era will be governed by the low-energy string equations of motion. Studying these equations for FRW spacetimes, we find that depending on the initial conditions when the stringy era starts, and on the time when it ends, there are a wide variety of ...
Goldwirth, Dalia S., Perry, Malcolm J.
openaire   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Gluon dominance model and cluster production [PDF]

, 2006
Gluon dominance model (GDM) studies multiparticle production in lepton and hadron processes. It is based on the QCD and phenomenological scheme of hadronization. The model describes well multiplicity distributions and their moments.
Kokoulina, Elena, Kutov, Andrey, Nikitin, Vladimir   +2 more
core   +3 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Quantitative Changes and Transformation of the SME Sector after the Shocks of 2022

Мир новой экономики
The aim of the article is to dentify structural changes in the SME sector, indicating positive dynamics and qualitative transformations of the sector during the adaptation of the Russian economy to the shocks of 2022. The methods of the research is based
A. A. Blokhin, K. V. Glukhov
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Кваліфікація монопольного становища на ринках та підстави притягнення до відповідальності за зловживання ним

Теорія і практика правознавства, 2018
Стаття присвячена розгляду теоретичних та практичних питань визначення монопольного становища суб’єктів господарюваннята застосування відповідальності до правопорушників за зловживання ним.
T. І. Shvydka
doaj   +1 more source

Stochastic dominance, regret dominance and regret-theoretic dominance

EURO Journal on Decision Processes, 2013
It is well known that stochastic dominance alone is insufficient for ensuring preferences when individuals experience regret. In this paper, we study two additional notions of dominance: (a) regret-theoretic dominance, which characterizes preferences in regret theory and (b) regret dominance, which characterizes preferences in mean-risk models with ...
Chin Hon Tan, Joseph C. Hartman
openaire   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source