Results 51 to 60 of about 145,057 (324)

Replication and discovery of musculoskeletal QTLs in LG/J and SM/J advanced intercross lines [PDF]

, 2018
AR056280 awarded to DAB and AL. AIHC supported by IMS and Elphinstone Scholarship from the University of Aberdeen.
Blizard, David A, Carbonetto, Peter, Gregory, Jennifer S, Gyekis, Joseph P, Hernandez Cordero, Ana I, Lionikas, Arimantas, Vandenbergh, David J, Verri, Gioia Riboni   +7 more
core   +1 more source

Allele interaction--single locus genetics meets regulatory biology. [PDF]

PLoS ONE, 2010
BACKGROUND: Since the dawn of genetics, additive and dominant gene action in diploids have been defined by comparison of heterozygote and homozygote phenotypes.
Arne B Gjuvsland, Erik Plahte, Tormod Adnøy, Stig W Omholt   +3 more
doaj   +1 more source

Estimation of genetic parameters for height using spatial analysis in Tsuga heterophylla full-sibling family trials in British Columbia [PDF]

, 2015
Non-spatial and spatial analyses were carried out to study the effects on genetic parameters in ten-year height growth data across two series of 10 large second-generation full-sib progeny trials of western hemlock [Tsuga heterophylla (Raf.) Sarg.] in ...
Cappa, Eduardo Pablo, Cartwright, C. V., Yanchuk, A. D.   +2 more
core   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Migration-selection balance at multiple loci and selection on dominance and recombination [PDF]

, 2013
A steady influx of a single deleterious multilocus genotype will impose genetic load on the resident population and leave multiple descendants carrying various numbers of the foreign alleles.
Proulx, Stephen R., Yanchukov, Alexey
core   +4 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Constraining models of dominance for nonsynonymous mutations in the human genome.

PLoS Genetics
Dominance is a fundamental parameter in genetics, determining the dynamics of natural selection on deleterious and beneficial mutations, the patterns of genetic variation in natural populations, and the severity of inbreeding depression in a population ...
Christopher C Kyriazis, Kirk E Lohmueller   +1 more
doaj   +1 more source

Quantitative genetics theory for genomic selection and efficiency of breeding value prediction in open-pollinated populations

Scientia Agricola, 2016
To date, the quantitative genetics theory for genomic selection has focused mainly on the relationship between marker and additive variances assuming one marker and one quantitative trait locus (QTL).
José Marcelo Soriano Viana, Hans-Peter Piepho, Fabyano Fonseca e Silva   +2 more
doaj   +1 more source

Seedling salt tolerance in tomato [PDF]

, 2011
Soils with higher concentrations of salt are becoming more and more a constraint for many crops to obtain high yields. Wild tomato species, adapted to adverse environments, are a potential reservoir for genes underlying quantitative trait loci (QTL ...
Bai, Y., Du, Y., Finkers, H.J., Heusden, A.W., van, Junming Li, J., Liu, L., Visser, R.G.F., Zhang, Pujuan   +7 more
core   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source