Impact of single nucleotide polymorphisms in leptin, leptin receptor, growth hormone receptor, and diacylglycerol acyltransferase (DGAT1) gene loci on milk production, feed, and body energy traits of UK dairy cows [PDF]
, 2008 The impact of 9 single nucleotide polymorphisms (SNP) in the leptin (LEP), leptin receptor (LEPR), growth hormone receptor (GHR), and diacylglycerol acyltransferase (DGAT1) gene loci on daily milk production, feed intake, and feed conversion, and weekly ...
Banos, G. +4 more
core +1 more source
On the Informativeness of Dominant and Co-Dominant Genetic Markers for Bayesian Supervised Clustering [PDF]
The Open Statistics % Probability Journal, 2011 We study the accuracy of Bayesian supervised method used to cluster individuals into genetically homogeneous groups on the basis of dominant or codominant molecular markers. We provide a formula relating an error criterion the number of loci used and the number of clusters.
Guillot, Gilles +1 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Families of children with cancer experience significant financial strain, even with universal healthcare. Indirect costs, such as productivity losses and non‐medical expenses, are rarely included in economic evaluations, and little is known about how effectively financial aid programmes alleviate this burden. Childhood brain tumours
Megumi Lim +8 more
wiley +1 more source
Genomic selection models for directional dominance: an example for litter size in pigs
Genetics Selection Evolution, 2018 Background The quantitative genetics theory argues that inbreeding depression and heterosis are founded on the existence of directional dominance.
Luis Varona +3 more
doaj +1 more source
Selection responses of means and inbreeding depression for female fecundity in Drosophila melanogaster suggest contributions from intermediate-frequency alleles to quantitative trait variation [PDF]
, 2007 The extent to which quantitative trait variability is caused by rare alleles maintained by mutation, versus intermediate-frequency alleles maintained by balancing selection, is an unsolved problem of evolutionary genetics.
Borthwick, Helen +2 more
core +1 more source
Molecular genetic heterogeneity in autosomal dominant drusen [PDF]
Journal of Medical Genetics, 2001 OBJECTIVE Autosomal dominant drusen is of particular interest because of its phenotypic similarity to age related macular degeneration. Currently, mutation R345W ofEFEMP1 and, in a single pedigree, linkage to chromosome 6q14 have been causally related to the disease. We proposed to investigate and quantify the roles
E E, Tarttelin +6 more
openaire +2 more sources
Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report
Pediatric Blood &Cancer, EarlyView.ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan +6 more
wiley +1 more source
Modeling Haplotype-Haplotype Interactions in Case-Control Genetic Association Studies
Frontiers in Genetics, 2012 Haplotype analysis has been increasingly used to study the genetic basis of human diseases, but models for characterizing genetic interactions between haplotypes from different chromosomal regions have not been well developed in the current literature ...
Li eZhang +4 more
doaj +1 more source
Statistical Modeling of Epistasis and Linkage Decay using Logic Regression [PDF]
, 2007 Logic regression has been recognized as a tool that can identify and model non-additive genetic interactions using Boolean logic groups. Logic regression, TASSEL-GLM and SAS-GLM were compared for analytical precision using a previously characterized ...
John A. Henning +3 more
core +1 more source
Placentophagia in Nonpregnant Nulliparous Mice: A Genetic Investigation [PDF]
, 1975 The genetic influence on the response of nonpregnant nulliparous mice to foster placenta was investigated. Two highly inbred strains (BALB/cBy and C57BL/6By), their F1 hybrids, a backcross generation, and seven recombinant-inbred strains derived from the
Eleftheriou, Basil E. +1 more
core +1 more source