Results 81 to 90 of about 145,057 (324)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Sex-linked genetic diversity originates from persistent sociocultural processes at microgeographic scales [PDF]

Royal Society Open Science, 2019
Population genetics has been successful at identifying the relationships between human groups and their interconnected histories. However, the link between genetic demography inferred at large scales and the individual human behaviours that ultimately ...
Ning Ning Chung, Guy S. Jacobs, Herawati Sudoyo, Safarina G. Malik, Lock Yue Chew, J. Stephen Lansing, Murray P. Cox   +6 more
doaj   +1 more source

ASIP Promoter Variants Predict the Sesame Coat Color in Shiba Inu Dogs

Veterinary Sciences, 2022
Animals exhibit a wide variety of genetically determined coat colors and pigmentation patterns that serve important roles in adaptation and communication.
Stepan N. Belyakin, Daniil A. Maksimov, Maria A. Pobedintseva, Petr P. Laktionov, Dinara Voronova   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Extended twin study of alcohol use in Virginia and Australia [PDF]

, 2018
Drinking alcohol is a normal behavior in many societies, and prior studies have demonstrated it has both genetic and environmental sources of variation.
Eaves, Lindon J, Heath, Andrew C, Maes, Hermine H, Martin, Nicholas G, Medland, Sarah E, Neale, Michael C, Verhulst, Brad   +6 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Missense BICD2 variants in fetuses with congenital arthrogryposis and pterygia

Human Genome Variation
Type 2 spinal muscular atrophy with lower extremity dominance (SMALED2) is caused by bicaudal D cargo adaptor 2 (BICD2) variants. However, the SMALED2 genotype and phenotype correlation have not been thoroughly characterized.
Layla Masuda, Akihiro Hasegawa, Hiromi Kamura, Fuyuki Hasegawa, Michihiro Yamamura, Kosuke Taniguchi, Yuki Ito, Kenichiro Hata, Osamu Samura, Aikou Okamoto   +9 more
doaj   +1 more source

Genetic correlations of fighting ability with somatic cells and longevity in cattle

Animal, 2020
The success in competitions may be stressful for animals and costly in terms of immune functions and longevity. Focusing on Aosta Chestnut and Aosta Black Pied cattle, selected for their fighting ability in traditional competitions, this study ...
C. Sartori, N. Guzzo, R. Mantovani
doaj   +1 more source

Analysis of reproductive performances during the formation of a synthetic rabbit strain

, 2005
[EN] In 1995, a synthetic rabbit strain ('2666') was formed at INRA for commercial meat purposesby crossing the INRA '2066' strain and the 'V' strain from the Polytechnical University of Valencia (Spain).The development of some reproductive traits and ...
Baselga, M., Brun, J.M.
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source