Results 71 to 80 of about 145,057 (324)

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Bose-Einstein Condensation in Competitive Processes [PDF]

, 2003
We introduce an irreversible discrete multiplicative process that undergoes Bose-Einstein condensation as a generic model of competition. New players with different abilities successively join the game and compete for limited resources. A player's future
Niebur, Ernst, Shimazaki, Hideaki
core   +2 more sources

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Reproductive characteristics, population genetics, and pairwise kinship inform strategic recovery of a plant species in a fragmented landscape

Conservation Science and Practice, 2023
Population genetics and understanding of mating systems provide fundamental information for conservation planning. Pairing these methods is a powerful tool in the study of threatened species, however, they are rarely applied in concert.
Chantelle A. T. Doyle, Jia‐Yee Samantha Yap, Jason Bragg, Maurizio Rossetto, Andrew Orme, Mark J. K. Ooi   +5 more
doaj   +1 more source

The effects of disruptive and stabilizing selection on body size in Drosophila melanogaster. III. Genetic analysis of two lines with different reactions to disruptive selection with mating of opposite extremes [PDF]

, 1974
A genetic analysis was made of two lines which when subjected to disruptive selection with compulsary mating of opposite extremes (D−) showed a different response viz.
Bos, M., Scharloo, W.
core   +3 more sources

Dominance reversals: the resolution of genetic conflict and maintenance of genetic variation [PDF]

Proceedings of the Royal Society B: Biological Sciences
Beneficial reversals of dominance reduce the costs of genetic trade-offs and can enable selection to maintain genetic variation for fitness. Beneficial dominance reversals are characterized by the beneficial allele for a given context (e.g. habitat, developmental stage, trait or sex) being dominant in that context but recessive where deleterious.
Karl Grieshop, Eddie K. H. Ho, Katja R. Kasimatis   +2 more
openaire   +4 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck. [PDF]

PLoS Genetics, 2015
Population bottlenecks followed by re-expansions have been common throughout history of many populations. The response of alleles under selection to such demographic perturbations has been a subject of great interest in population genetics.
Daniel J Balick, Ron Do, Christopher A Cassa, David Reich, Shamil R Sunyaev   +4 more
doaj   +1 more source

The impact of epistasis in the heterosis and combining ability analyses

Frontiers in Plant Science, 2023
The current theoretical knowledge concerning the influence of epistasis on heterosis is based on a simplified multiplicative model. The objective of this study was to assess how epistasis affects the heterosis and combining ability analyses, assuming ...
José Marcelo Soriano Viana
doaj   +1 more source

The pattern and distribution of deleterious mutations in maize [PDF]

, 2013
Most non-synonymous mutations are thought to be deleterious because of their effect on protein sequence. These polymorphisms are expected to be removed or kept at low frequency by the action of natural selection, and rare deleterious variants have been ...
Mezmouk, Sofiane, Ross-Ibarra, Jeffrey
core   +2 more sources