Results 81 to 90 of about 713,409 (294)

A Novel Root-Knot Nematode Resistance QTL on Chromosome Vu01 in Cowpea. [PDF]

open access: yes, 2019
The root-knot nematode (RKN) species Meloidogyne incognita and M. javanica cause substantial root system damage and suppress yield of susceptible cowpea cultivars.
Guo, Yi-Ning   +7 more
core   +2 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Critical mutation rate has an exponential dependence on population size in haploid and diploid populations [PDF]

open access: yes, 2013
Understanding the effect of population size on the key parameters of evolution is particularly important for populations nearing extinction. There are evolutionary pressures to evolve sequences that are both fit and robust.
Aston, E, Channon, A, Day, C, Knight, CG
core   +5 more sources

Accounting for dominance to improve genomic evaluations of dairy cows for fertility and milk production traits

open access: yesGenetics Selection Evolution, 2016
BackgroundDominance effects may contribute to genetic variation of complex traits in dairy cattle, especially for traits closely related to fitness such as fertility.
H. Aliloo   +4 more
semanticscholar   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

open access: yesMolecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima   +6 more
wiley   +1 more source

Genetic correlations of fighting ability with somatic cells and longevity in cattle

open access: yesAnimal, 2020
The success in competitions may be stressful for animals and costly in terms of immune functions and longevity. Focusing on Aosta Chestnut and Aosta Black Pied cattle, selected for their fighting ability in traditional competitions, this study ...
C. Sartori, N. Guzzo, R. Mantovani
doaj   +1 more source

Replication and discovery of musculoskeletal QTLs in LG/J and SM/J advanced intercross lines [PDF]

open access: yes, 2018
AR056280 awarded to DAB and AL. AIHC supported by IMS and Elphinstone Scholarship from the University of Aberdeen.
Blizard, David A   +7 more
core   +1 more source

Genomic evaluation by including dominance effects and inbreeding depression for purebred and crossbred performance with an application in pigs

open access: yesGenetics Selection Evolution, 2016
BackgroundImproved performance of crossbred animals is partly due to heterosis. One of the major genetic bases of heterosis is dominance, but it is seldom used in pedigree-based genetic evaluation of livestock.
T. Xiang   +3 more
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Missense BICD2 variants in fetuses with congenital arthrogryposis and pterygia

open access: yesHuman Genome Variation
Type 2 spinal muscular atrophy with lower extremity dominance (SMALED2) is caused by bicaudal D cargo adaptor 2 (BICD2) variants. However, the SMALED2 genotype and phenotype correlation have not been thoroughly characterized.
Layla Masuda   +9 more
doaj   +1 more source

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