Results 51 to 60 of about 1,326,337 (292)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Consistent testing for stochastic dominance: a subsampling approach [PDF]

We propose a procedure for estimating the critical values of the extended Kolmogorov- Smirnov tests of First and Second Order Stochastic Dominance in the general K-prospect case.
Yoon-Jae Wang, Esfandiar Maasoumi, Oliver Linton   +2 more
core   +2 more sources

A Pareto Dominance Principle for Data-Driven Optimization

Operations Research
Our paper proposes an effective way to make decisions based on data for uncertain situations. In simple terms, a data-driven decision is just a choice we make by looking at the available data. We express this choice as the best one according to a model we create from the data. The quality of this decision is judged by how well it performs in situations
Tobias Sutter, Bart P. G. Van Parys, Daniel Kuhn 0001   +2 more
openaire   +6 more sources

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Learning the dominance in diploid genetic algorithms for changing optimization problems [PDF]

, 2007
Using diploid representation with dominance scheme is one of the approaches developed for genetic algorithms to address dynamic optimization problems.
Yang, S
core   +5 more sources

Dominance learning in diploid genetic algorithms for dynamic optimization problems [PDF]

, 2006
Copyright @ 2006 YangThis paper proposes an adaptive dominance mechanism for diploidy genetic algorithms in dynamic environments. In this scheme, the genotype to phenotype mapping in each gene locus is controlled by a dominance probability, which is ...
Yang, S, Shengxiang Yang, Yang, Shengxiang   +2 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

TESTING FOR RESTRICTED STOCHASTIC DOMINANCE [PDF]

Asymptotic and bootstrap tests are studied for testing whether there is a relation of stochastic dominance between two distributions. These tests have a null hypothesis of nondominance, with the advantage that, if this null is rejected, then all that is ...
Jean-Yves Duclos, Russell Davidson
core   +2 more sources