Results 61 to 70 of about 1,326,337 (292)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Consistency of the Presidential System in Indonesia

open access: yesSriwijaya Law Review, 2018
The current presidential system in Indonesia is the result of the amendments of the 1945 Constitution. Prior to Indonesian reform, the presidential system was influenced by a strong parliamentary pattern in which the president was responsible for the ...
Kuswanto Kuswanto
doaj   +1 more source

Basic tendencies in the evolution of the principle of immediacy in general criminal procedure in Serbia [PDF]

open access: yesZbornik Radova: Pravni Fakultet u Novom Sadu, 2023
The subject of our research is the evolution of the principle of immediacy in general criminal proceedings in Serbian law, with the aim of observing the basic tendencies in that development.
Brkić Snežana S.
doaj  

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Neo-Confucianism of Joseon dynasty––its theoretical foundation and main issues

open access: yesAsian Studies, 2016
The theoretical foundation of Joseon Neo-Confucianism, which started with the theory of the Principle and Material Force (Seongriseol), seeks for the fundamental values of all things in the universe by means of the theories of Cosmology (Ujuron) and Mind
Haesung LEE
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

On the principles of the organizaion of text in udarniks' sketches of the late 1920 - early 1930

open access: yesRUDN Journal of Studies in Literature and Journalism, 2012
The author analyzes the composition of the text of the udarnik's sketch to demonstrate the realization of the principle of cinematographicness (one of the basic principles of poetics of the late 1920 - early 1930) in the literary text.
O S Zavjalova
doaj  

Equity Criteria Based on the Dominance Principle and Individual Preferences: Refinements of the Consensus Approach

open access: yes, 2018
This paper examines the problem of the indexing dilemma in the context of an ordinal interpersonal comparison of individual situations and proposes a new class of equity criteria based on the dominance principle and individual preferences. First, we show
Sakamoto, Norihito
core  

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Elitism and Stochastic Dominance [PDF]

open access: yes
Stochastic dominance has typically been used with a special emphasis on risk and inequality reduction something captured by the concavity of the utility function in the expected utility model.
Patrick Moyes, Stephen Bazen
core   +2 more sources

Home - About - Disclaimer - Privacy