Results 161 to 170 of about 1,180,437 (249)

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

A Curious Case of Patterned Scarring Alopecia

JEADV Clinical Practice, EarlyView.
Jeta Buch, Pooja S. Shah, Ashish Jagati, Santoshdev P. Rathod   +3 more
wiley   +1 more source

Humidity Ramp Protocols Systematically Underestimate Human Heat Tolerance Limits

Safety Science and Technology, EarlyView.
Short dwell times in humidity‐ramp protocols (Δt/τ≪1 ${\Delta }t/\tau \mathit{\ll }1$) prevent human core temperature from reaching equilibrium, causing premature inflection points and systematic underestimation of critical environmental limits by ∼3°C–4°C.
Fèlix Faming Wang, Yi Xu, Haojian Wang, Min Cui, Xue Hou, Boan Wei, Xiong Shen   +6 more
wiley   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Congenital Sparse and Brittle Hair in a Child

JEADV Clinical Practice, EarlyView.
Sanket Bishokarma, Saru Pradhan, Niraj Parajuli   +2 more
wiley   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source

Organelle reorganization in bovine oocytes during dominant follicle growth and regression. [PDF]

Reprod Biol Endocrinol, 2015
Dadarwal D, Adams GP, Hyttel P, Brogliatti GM, Caldwell S, Singh J.   +5 more
europepmc   +1 more source

Monilethrix Presenting With Diffuse Fragile Hair in an Adult Female

JEADV Clinical Practice, EarlyView.
Mandy Robertson, Jeffrey Donovan
wiley   +1 more source

Cortisol concentrations in hair are biomarkers of health status and seasonal change, but not urbanisation, in wolves

Wildlife Biology, EarlyView.
Wolves have reclaimed much of their former range in Europe, including areas with a high human footprint, yet the physiological impacts of human‐associated stressors remain poorly understood. We first examined methodological factors affecting hair cortisol concentrations (HCC) in wolves by using a ‘shave/re‐shave' design to assess hair growth rate and ...
Gwendolyn Wirobski, Carmela Musto, Rudy Brogi, Martina Lazzaroni, Rupert Palme, Yasmina Wukovich, Fanni Kertész, Ágnes Szabó, Chiara Garbarino, Marco Gobbi, Lorella Barca, Mauro Delogu, The Wolf Network, Friederike Range, Marco Apollonio, Sarah Marshall‐Pescini   +15 more
wiley   +1 more source

Linear Cutaneous and Craniofacial Anomalies in a Female Infant

JEADV Clinical Practice, EarlyView.
Kim H. Tran, Kimia Ameri, Joseph M. Lam
wiley   +1 more source