Results 171 to 180 of about 23,859 (257)

Regulation and regulatory role of WNT signaling in potentiating FSH action during bovine dominant follicle selection. [PDF]

PLoS One, 2014
Gupta PS, Folger JK, Rajput SK, Lv L, Yao J, Ireland JJ, Smith GW.   +6 more
europepmc   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Influence of the dominant follicle on the superovulatory response in cattle

Asian-Australasian Journal of Animal Sciences, 1998
R. S. Manik, S. K. Singla, P. Palta, M. L. Madan   +3 more
openaire   +1 more source

Genomic Evolution and Immune Contexture With Therapeutic Relevance in Pancreatic Neuroendocrine Neoplasms

Cancer Science, EarlyView.
Lineage‐dependent immunogenomic landscapes and biologically informed therapy in pancreatic neuroendocrine neoplasms. Pancreatic neuroendocrine neoplasms display lineage‐dependent immunogenomic landscapes, in which genomic alterations, epigenetic states, antigen‐presentation status, immune‐cell infiltration, and suppressive microenvironments co‐evolve ...
Yohei Tabe, Eito Nakagawa, Daisuke Asano, Eriko Katsuta, Daisuke Ban, Shogo Kumagai   +5 more
wiley   +1 more source

Immunohistochemical analysis of MMP-1 and 2 in patients with lichen planopilaris and frontal fibrosing alopecia. [PDF]

An Bras Dermatol
Zac RI, Pilar EFS, Moraes JC, Moura ICG, Pedrosa MS, da Costa A.   +5 more
europepmc   +1 more source

Diverging in Vivo Immune Response Patterns After Oral Food Challenge in Peanut Allergic Adults

Clinical &Experimental Allergy, EarlyView.
After the oral food challenge, peanut (PN)‐allergic adults were monitored over 4 weeks, which revealed diverging immune response patterns, with strong responders (SR) exhibiting heightened Ara h 2+ B cell expansion, PN sIgE induction and increasing PN‐specific Tconv. Weak responders (WR) had more activated PN‐specific Tregs.
Florent Fauchère, Aikaterina Alexiou, Veronika Höfer, Kirsten Beyer, Sabine Dölle‐Bierke, Andreas Thiel, Margitta Worm, Julian Braun   +7 more
wiley   +1 more source

Successful ovulation and pregnancy with pulsatile GnRH pump therapy in a polycystic ovary syndrome (PCOS) patient: a case report. [PDF]

Front Endocrinol (Lausanne)
Wang S, Xiong Y, Qin L, Xu K, Cheng M.
europepmc   +1 more source

Malignancy in Pediatric Hyperfunctioning Thyroid Nodules: A Case Report and Literature Review

Clinical Endocrinology, EarlyView.
ABSTRACT Background Thyroid nodules are rare in children but carry a markedly higher risk of malignancy compared to adults (20%–26% vs. 5%). Hyperfunctioning thyroid nodules are exceptionally uncommon in the pediatric population and are typically benign.
Cristina Clausi, Simona Censi, Jacopo Maria Arnone, Giulia Messina, Ilaria Piva, Fausto Cortese, Loris Bertazza, Susi Barollo, Francesca Galuppini, Marco Zarantonello, Maurizio Iacobone, Gianmaria Pennelli, Caterina Mian   +12 more
wiley   +1 more source

Association between self-reported poor sleep status and ovulation rate in Chinese women with fertility intentions: a multicentre prospective cohort study protocol. [PDF]

BMJ Open
Su NJ, Huang J, Li H, Chen H, Wang L, Wang S, Huang K, Wang J, Huang J, Liao Y, Li L, Xiong Z, Ren H, Liu B, Chen D, Ma N, Yin L, Huang C, Zhang X, Liu F.   +19 more
europepmc   +1 more source

Single‐Cell and Spatial Analysis Reveal the Differences Between Left‐Sided and Right‐Sided Colorectal Cancer

Cell Proliferation, EarlyView.
Single‐cell and spatial analysis revealed distinct CRC microenvironments by tumour laterality. Right‐sided tumours showed enhanced germinal centre B cells, CXCL13+ T cells, and organized TLS‐immune crosstalk via CCL19/21‐CCR7, suggesting better immunotherapy response.
Zongnai Zhang, Jiaqi Xu, Yingchao Wu, Tao Liu, Junling Zhang, Mai Zhou, Jie Qiao, Heng Pan, Xin Wang   +8 more
wiley   +1 more source