Results 91 to 100 of about 480,644 (302)

PREVENTING THE ABUSE OF MONOPOLY (DOMINANT) POSITION

, 2016
This article studies the dynamics of abuse of monopoly (dominant) position. Economic and legal means of preventing abuse of monopoly (dominant) position have been justified.
Грудницький, Василь Миколайович
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Determination of the relationship between the wrist isokinetic muscle strenght and the grip strength in tennis players aged between 12-14

Orthopaedic Journal of Sports Medicine, 2017
Aim: The purpose of this study is to determine the relationship between isokinetic wrist muscle strenght and grip strength in tennis players aged between 12-14.
Bihter Akınoğlu, Tuğba Kocahan, Necmiye Ün Yıldırım, Çağlar Soylu, Adnan Hasanoğlu   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Insights from the Slovak Hybrid Mail Services Case.Case Comment to the Judgement of the General Courtof 25 March 2015 and Order of Court of Justice of the EUof 30 June 2016Slovenská pošta v Commission (Cases T-556/08, C-293/15P) [PDF]

Yearbook of Antitrust and Regulatory Studies, 2017
Karolis Kačerauskas
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Market competition in the European union and abuse dominant position

, 2016
U radu je obrađeno tržišno natjecanje u Europskoj uniji i zlouporaba dominantnih položaja. Radnja je podijeljena na 5 poglavlja, a ona su podijeljena u uže cjeline.
Ivanišević, Renata
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Duality of the legal regulation of a dominant position in EU competition law [PDF]

, 2012
Résumé The presented work addresses the issue of the double-tracking nature of a dominant position in European competition law. The aim of the integration efforts during the establishment of the EU was the creation of an internal market, especially the ...
Pavel, Jan
core   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Comparative analysis of fencer's dominant and non-dominant shoulder muscles strength, length and scapula position.

, 2016
Fencing is an asymmetric sport that can cause shoulder muscles disbalance. Bilateral differences of muscle strength or length are related to shoulder pain, poorer sport performance and can even lead to trauma. The aim of research work.
Pacevičiūtė, Rimantė,
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