Results 101 to 110 of about 480,644 (302)
Collective dominant position in the internal market
, 2023 Η Ευρωπαϊκή Ένωση έχει θεσπίσει, μέσω του πρωτογενούς και του παράγωγου δικαίου, ένα σύνολο κανόνων του Δικαίου του Ανταγωνισμού που αποσκοπούν στην οριοθέτηση των πολιτικών των Κρατών Μελών και των θεσμικών οργάνων καθώς και των επιχειρήσεων ώστε να ...
Στασινοπούλου Γεωργία-Μαρία +1 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
European dominant position and american monopolization: a unifying approach from basic game theory
PSL Quarterly Review, 2012 In this paper I use basic game theory tools to explore the logical consequences of some fundamental legal definitions of European and American antitrust.
Pier Luigi Parcu
doaj +1 more source
Abuse of a Dominant Position within European Union Maritime Transport
, 2021 European Union competition policy is shaped rather differently in particular economic sectors. The best example of this is maritime transport. In recent years this area has found itself at the center of the European Commission's attention.
Resiak, Agnieszka
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Is it possible to define dominant position on the market?
, 2013 This thesis aims to reveal whether it is economically meaningful to define dominant position on the market. The term "dominant position" is one of the key terms in the anti-trust legislation.
Topinková, Kateřina
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FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source