Results 121 to 130 of about 436,818 (327)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Éprouver la domination. Par-delà le travail émotionnel

open access: yesTracés
The concept of emotion work developed by Arlie Hochschild has now become essential to any reflection on the sensitive experience of domination. Hochschild’s research, which uncovers a previously invisible form of exploitation based on emotional control ...
Manuel Schotté
doaj   +1 more source

O GRUPO LEMANN E O NOVO PAPEL DOS APARELHOS PRIVADOS DE HEGEMONIA NO CAMPO DA EDUCAÇÃO NO BRASIL

open access: yesRevista Trabalho, Política e Sociedade, 2019
The article analyzes the performance of the Lemann Group which, through the Lemann Foundation, has been acting on several fronts of the public education policy in Brazil.
Maria Teresa Cavalcanti de Oliveira
doaj   +1 more source

Quantitative weighted estimates for Harmonic analysis operators in the Bessel setting by using sparse domination [PDF]

open access: hybrid, 2022
Víctor Almeida   +3 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Finiteness of outer automorphism groups of random right-angled Artin groups

open access: yes, 2011
We consider the outer automorphism group Out(A_Gamma) of the right-angled Artin group A_Gamma of a random graph Gamma on n vertices in the Erdos--Renyi model.
Erdős, Matthew B Day
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Bibliometric Analysis of Male Domination Articles Since 1958-2022

open access: diamond, 2023
Ahmad Hamidi   +7 more
openalex   +2 more sources

Regional Variation in Attitude of Mental Health Professionals Towards Tackling Illicit Drug-use and Drug-related Disorders [PDF]

open access: yes, 2017
This study sought to assess the attitudes of Mental Health Professionals (MHPs) towards tackling illicit drug use and drug-related disorders in Nigeria and to explore regional variations in attitude. Based on the validated Substance Abuse Attitude Survey
Akinola, O. (Olubusayo)   +3 more
core  

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