Results 41 to 50 of about 12,409,454 (287)

Donation after circulatory death – activity review in the Asian region

Transplantation Reports, 2022
Transplantation remains the optimum treatment for many patients. The availability of donor organs has failed to keep pace with demand, resulting in an ever-increasing waiting list of potential recipients.
Zsolt Kaposztas
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

A multicenter analysis of lung transplantation outcomes comparing donation after circulatory death and donation after brain death

JHLT Open
Background: Donor organ shortage is a barrier to lung transplantation. Donation after circulatory death (DCD) may offer a solution, although it is underutilized. The objective of this study was to compare survival and other postoperative outcomes between
Mohammed Abul Kashem, MD, PhD, Gabriel Loor, MD, Matthew Hartwig, MD, Dirk Van Raemdonck, MD, PhD, Mauricio Villavicencio, MD, Fabio Ius, MD, Kamrouz Ghadimi, MD, Jawad Salman, MD, Satish Chandrashekaran, MD, Tiago Machuca, MD, PhD, Pablo G. Sanchez, MD, PhD, Kathirvel Subramaniam, MD, Arne Neyrinck, MD, PhD, Hannah Calvelli, BA, Michael Warnick, BS, Huaqing Zhao, PhD, Stephen Huddleston, MD, PhD, Asishana Osho, MD, Ethan D'Silva, MD, Uma Ramamurthy, PhD, Andres Leon Pena, MD, Marcelo Salan-Gomez, MD, Andrew Shaffer, MD, Nathaniel Langer, MD, Amir Emtiazjoo, MD, Yoshiya Toyoda, MD, PhD   +25 more
doaj   +1 more source

Pre-arrest doxycycline protects donation after circulatory death kidneys

Scientific Reports, 2020
Kidney injury during donation after circulatory determination of death (DCDD) includes warm ischemic (WI) injury from around the time of asystole, and cold ischemic (CI) injury during cold preservation.
Michael Moser, Sarah Schmid, Katherine Sawicka, Tamalina Banerjee, Erick McNair, Jolanta Sawicka, Iwona Bil-Lula, Grzegorz Sawicki   +7 more
doaj   +1 more source

Prioritizing direct heart procurement in organ donors after circulatory death does not jeopardize lung transplant outcomesCentral MessagePerspective

JTCVS Techniques, 2022
Background: Controlled donation after circulatory death (cDCD) has become a standard in liver, kidney, and lung transplantation (LTx). Based on recent innovations in ex vivo heart preservation, heart transplant centers have started to accept cDCD heart ...
Stefan Schwarz, MD, PhD, Johannes Gökler, MD, Roxana Moayedifar, MD, Clemens Atteneder, MD, Giovanni Bocchialini, MD, Alberto Benazzo, MD, PhD, Thomas Schweiger, MD, PhD, Peter Jaksch, MD, Andreas O. Zuckermann, MD, Arezu Z. Aliabadi-Zuckermann, MD, Konrad Hoetzenecker, MD, PhD   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Heart transplantation with donation after circulatory determination of death.

, 2014
The constant shortage of available organs is a major obstacle and limiting factor in heart transplantation; the discrepancy between the number of donors and potential recipients leads to waiting-list mortality of 10-12% per year in Europe and the USA. If
Tevaearai, Hendrik, Florian Dick, Mathys, Veronika, Carrel, Thierry, Veronika Mathys, Dornbierer, Monika, Monika Dornbierer, Hendrik T. Tevaearai, Thierry P. Carrel, Dick, Florian, Sarah L. Longnus, Longnus, Sarah L.   +11 more
core   +1 more source

Solid organ transplantation originating from uncontrolled donation after circulatory death in Europe: a narrative review

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Human organ transplantation has begun in the 1960s with donation after circulatory death. At that time this was named non heart beating donation, later donation after cardiac death and nowadays it is named donation after circulatory death.
Yann Pionnier, Tom Darius, Andrea Penaloza, Francoise Steenebruggen, Florence Dupriez, Arne Neyrinck, Cornelia Genbrugge   +6 more
doaj   +1 more source