Results 81 to 90 of about 28,065 (271)
Journal of Pharmacological Sciences, 2017 Donepezil is a potent and selective acetylcholinesterase inhibitor developed for the treatment of Alzheimer's disease. In the present study, we investigated the responses of astrocytes to bradykinin, an inflammatory mediator, and the effect of donepezil ...
Kouki Makitani +4 more
doaj +1 more source
Scientific Reports, 2019 Adolescent intermittent ethanol (AIE) exposure diminishes neurogenesis and dendritic spine density in the dentate gyrus. The cholinesterase inhibitor, donepezil (Aricept), reverses AIE effects on dendritic spines, possibly by interacting with ...
H. Swartzwelder +5 more
semanticscholar +1 more source
Journal of Sleep Research, EarlyView.ABSTRACT Parasomnias are abnormal behaviours or mental experiences during sleep or the sleep–wake transition. As disorders of arousal (DOA) or REM sleep behaviour disorder (RBD) can be difficult to capture in the sleep laboratory and may need to be diagnosed in large communities, new home diagnostic devices are being developed, including actigraphy ...
Claudia Picard‐Deland +5 more
wiley +1 more source
Drug Design, Development and Therapy, 2020 Seok Kyu Yoon,1 Kyun-Seop Bae,1 Dong Hyun Hong,2 Seong Su Kim,2 Young Kweon Choi,2 Hyeong-Seok Lim1 1Department of Clinical Pharmacology and Therapeutics, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Republic of Korea ...
Yoon SK +5 more
doaj
Effects of Donepezil on Clinical Symptoms, Language, and Executive Skills in Individuals with Autism Spectrum Disorder: A Systematic Review [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریزBackground. This study assessed the potential efficacy of donepezil in treating autism spectrum disorder (ASD), a neurodevelopmental condition characterized by social communication difficulties and repetitive behaviors. Donepezil, primarily used to treat
Shahrokh Amiri +4 more
doaj +1 more source
Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 A new series of multifunctional hybrids, based on the structure of the donepezil (DNP) drug, have been developed and evaluated as potential anti Alzheimer’s disease (AD) agents.
L. Piemontese +7 more
semanticscholar +1 more source
Psychiatry and Clinical Neurosciences, EarlyView.Aim A GGC repeat expansion in the 5′ untranslated region of NOTCH2NLC is a genetic cause of Neuronal Intranuclear Inclusion Disease (NIID) that exhibits cognitive, motor, and autonomic dysfunction. Our objective is to determine whether there are undiagnosed NIID cases in a psychiatry‐based dementia‐enriched cohort and to identify their clinical ...
Tesshin Miyamoto +15 more
wiley +1 more source
N‐Insertion of Diazonium Salts Into Ketone Derivatives
Angewandte Chemie, Volume 137, Issue 29, July 14, 2025.Diazonium salts insert into ketones and their silyl enol ethers through a sequence of α‐azenylation and ring expansion via an N‐iminoaziridinium species. Coupled with an efficient N‐N bond cleavage, this protocol offers a mild alternative to Beckmann rearrangements and a powerful tool for skeletal editing of ketones.
Mohammed Anif Pasha +3 more
wiley +2 more sources
Basic and Clinical Neuroscience, 2019 Introduction: Donepezil (DON), an Acetylcholinesterase Inhibitor (AChEI), is widely used in the treatment of Alzheimer’s Disease (AD). The current study aimed at evaluating the effect of donepezil hydrochloride on pyramidal neuron response in CA1 region ...
Azade Eskandary +3 more
doaj
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2019 Introduction Donepezil is a widely used cholinesterase inhibitor in the management of Alzheimer's disease. Despite large‐scaled evidence for its efficacy, elevated peripheral ACh levels often lead to side effects and are dose limiting.
Anne Catrien Baakman +6 more
doaj +1 more source