Results 61 to 70 of about 21,434 (231)

Pharmaco-fUS for Characterizing Drugs for Alzheimer’s Disease – The Case of THN201, a Drug Combination of Donepezil Plus Mefloquine

Frontiers in Neuroscience, 2020
Donepezil is a potent acetylcholinesterase inhibitor, largely used worldwide to alleviate cognitive symptoms in Alzheimer’s disease (AD). Beyond the widely described neuronal impact of donepezil, it was recently shown that targeting connexins, the ...
Benjamin Vidal, Benjamin Vidal, Marine Droguerre, Marco Valdebenito, Luc Zimmer, Luc Zimmer, Luc Zimmer, Michel Hamon, Franck Mouthon, Mathieu Charvériat   +9 more
doaj   +1 more source

Neuroprotective effects of donepezil against Aβ25-35-induced neurotoxicity

European Journal of Medical Research, 2022
Purpose The purpose of this study was to investigate the neuroprotective effect of donepezil against β-amyloid25-35 (Aβ25-35)-induced neurotoxicity and the possible mechanism. Methods PC12 cells were conventionally cultured. Serial concentrations of Aβ25-
Bu-Lang Gao, Ning-Ning Che, Xue Li, Chun-Feng Ren   +3 more
doaj   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

The Efficacy of Licensed-Indication Use of Donepezil and Memantine Monotherapies for Treating Behavioural and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease: Systematic Review and Meta-Analysis

Dementia and Geriatric Cognitive Disorders Extra, 2011
Background/Aims: Behavioural and psychological symptoms of dementia (BPSD) in Alzheimer’s disease (AD) greatly increase caregiver burden. The abilities of donepezil and memantine to manage BPSD within their licensed indications in AD were compared ...
I.A. Lockhart, M.E. Orme, S.A. Mitchell
doaj   +1 more source

Non‐Invasive Brain Targeted Delivery of Cannabidiol for Alleviating Neuroinflammatory Disease

Advanced Materials, Volume 38, Issue 31, 2 June 2026.
The glucose‐functionalized nanoparticles (GNPs) are developed for the brain‐targeted delivery of cannabidiol (CBD). GNPs bypass the blood‐brain barrier (BBB) via glucose transporter‐1 (GLUT‐1) and release CBD in response to reactive oxygen species (ROS).
Yibin Wang, Yundong Li, Xin Wang, Yaning Hou, Wei Deng, Meng Zheng, Yan Zou, Bingyang Shi   +7 more
wiley   +1 more source

Donepezil-Inspired Multitargeting Indanone Derivatives as Effective Anti-Alzheimer’s Agents

In continuous efforts to develop anti-Alzheimer’s agents, we rationally designed and synthesized a series of multitargeting molecules by incorporating the essential molecular features of the standard drug donepezil.
Sahil Sharma (790739), Harbinder Singh (6725993), Shubham Thakur (12126044), Preet Mohinder Singh Bedi (4514314), Harmandeep Kaur Gulati (6725981), Venus Singh Mithu (10525386), Kavita Bhagat (6725969), Jatinder Vir Singh (12126041), Harjeet Singh (187475), Nitish Kumar (10197335), Harpreet Singh (677440), Anchal Sharma (3465371)   +11 more
core   +1 more source

Donepezil Treatment in Ethnically Diverse Patients with Alzheimer Disease [PDF]

, 2015
ObjectiveTo compare the outcome of donepezil treatment in ethnically diverse Alzheimer disease (AD) patients with ethnically diverse AD patients who did not receive donepezil.MethodsPatients meeting NINCDS-ADRA criteria for probable or possible AD from a
Taylor, Joy L., Taylor, Joy L, Kraemer, Helena C., Yesavage, Jerome A, Yaffe, Kristine, Ashford, John W., Ashford, John W, Ringman, John M, O'Hara, Ruth, Tinklenberg, Jared R., Yesavage, Jerome A., Kraemer, Helena C, Ringman, John M., Tinklenberg, Jared R, California Alzheimer's Disease Centers   +14 more
core   +1 more source

Synthesis of Donepezil Hydrochloride via Chemoselective Hydrogenation

, 2016
Synthesis of Donepezil Hydrochloride via Chemoselective ...
Nilay Bhatt (1867765), Anand Vardhan (1867777), Ajay Singh Rawat (1867774), Chandrakant Belwal (1867768), Raju Kharatkar (1867771), Sachin Pande (1867762)   +5 more
core   +3 more sources

Electrochemical Hofmann Rearrangement for Modular Synthesis of Unsymmetrical Ureas and Late‐Stage Modification of Drugs

Advanced Science, Volume 13, Issue 31, 4 June 2026.
An electrochemical Hofmann rearrangement of amide involving amine or other amide nucleophiles has been developed. The use of NaI guarantees the feasibility and compatibility of the electrosynthesis protocol, which enables highly chemoselective synthesis of unsymmetrical N‐acylureas from two different amides, as well as the production of unsymmetrical ...
Xue‐Qing Mou, Xiao Zha, Yu‐Rui Jian, Shao‐Xing Zhong, Xin‐Yu Fu, Sheng‐Yang Xu, Wei Xiang, Bao‐Dong Cui, Yun Zhang, Yong‐Zheng Chen   +9 more
wiley   +1 more source

Donepezil in vascular dementia: a randomized, placebo-controlled study

, 2003
Objective: To evaluate the efficacy and tolerability of donepezil in patients with vascular dementia (VaD).Methods: Patients (n = 616; mean age, 75.0 years) with probable or possible VaD, according to National Institute of Neurological Disorders and ...
Wilkinson, D., Kertesz, A., Pratt, R.D., Donepezil 308 Study Group, Doody, R., Donepezil 308 Study Group, Helme, R., Mintzer, J, Taubman, K.   +7 more
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