Results 161 to 170 of about 73,720 (258)

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

Comparative Whey Proteome Profiling of Donkey Milk With Human and Cow Milk. [PDF]

Front Nutr, 2022
Zhang X, Jiang G, Ji C, Fan Z, Ge S, Li H, Wang Y, Lv X, Zhao F.   +8 more
europepmc   +1 more source

Rapamycin Reduces Amyloid‐β Plaques and Improves Behavioral Performance in a Sex‐Dependent Manner in Mouse Models of Amyloidosis

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Rapamycin treatment reduced cerebral Aβ plaque burden, alleviated neuritic dystrophy, suppressed glial hyperactivation, and increased plaque‐associated microglial recruitment in amyloidosis mouse models, resulting in improved memory performance. Mechanistically, rapamycin enhanced microglial lysosomal degradation, facilitated lipid droplet clearance in
Shihui Guo, Weishan Fu, Yating Wang, Qi Liu, Jiaxin Li, Kai Guo, Hongsheng Zhang   +6 more
wiley   +1 more source

Microbiological Quality of Raw Donkey Milk from Serbia and Its Antibacterial Properties at Pre-Cooling Temperature. [PDF]

Animals (Basel), 2023
Šarić L, Premović T, Šarić B, Čabarkapa I, Todorić O, Miljanić J, Lazarević J, Karabasil N.   +7 more
europepmc   +1 more source

Community adaptation of action research designs for land restoration in communal grazing lands [PDF]

, 2020
Nganga, Irene N., Sircely, Jason A., Temesgen, Tamene   +2 more
core  

CDC42‐Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity

Glia, Volume 74, Issue 3, March 2026.
CDC42‐effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin‐dependent scaffolding of myelin. Myelin outfoldings do not cause secondary neuropathology per se. ABSTRACT The regular structure of CNS myelin requires specialized structural proteins, including septin ...
Sophie Hümmert, Joana Paes de Faria, Olaf Jahn, Ege Bilgin, Nikola Łukasik, Chethana Rao, Mišo Mitkovski, Fritz Benseler, Nils Brose, Sophie B. Siems, Sandra Goebbels, Wiebke Möbius, Helge Ewers, João B. Relvas, Hauke B. Werner   +14 more
wiley   +1 more source

Effects of donkey milk on UVB-induced skin barrier damage and melanin pigmentation: A network pharmacology and experimental validation study. [PDF]

Front Nutr, 2023
Li A, He H, Chen Y, Liao F, Tang J, Li L, Fan Y, Li L, Xiong L.   +8 more
europepmc   +1 more source

Prostaglandin D2 Synthase Controls Schwann Cells Metabolism and Peripheral Myelin Homeostasis

Glia, Volume 74, Issue 3, March 2026.
Prostaglandin D2 Synthase (L‐PGDS) controls PPNS myelin lipids’ composition and Schwann cells energetic metabolism In the absence of L‐PGDS Schwann cells turn to acetate as the main energetic source. These metabolic changes result in ketone bodies production to preserve neuronal survival.
Amelia Trimarco, Matteo Audano, Rosa La Marca, Marta Pellegatta, Paolo Canevazzi, Mariaconcetta Cariello, Marta Falco, Silvia Pedretti, Gabriele Imperato, Alessandro Cestaro, Paola Podini, Giorgia Dina, Angelo Quattrini, Luca Massimino, Donatella Caruso, Nico Mitro, Carla Taveggia   +16 more
wiley   +1 more source

Community conversations on animal welfare [PDF]

, 2020
Demeke, Y., Doyle, R., Kumbe, A., Lemma, Mamusha, Mekonnen, Mesfin, Wieland, Barbara   +5 more
core  

Neuronal Extracellular Vesicles Carrying APOE Downregulate Filament Actin Polymerization Signaling to Inhibit Synapse Formation in Alzheimer's Disease

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
During AD progression, EVs derived from APP/PS1 neurons transport APOE into healthy neurons, potentially interacting with neuronal APOE receptors (LRP1, LDLR, VLDLR) to transduction the signaling. This signaling inhibits Rac1‐GTP activation and subsequently downregulates F‐actin polymerization through the Rac1‐N‐WASP‐Arp2/3 pathway.
Yang Yu, Zhixin Ma, Taixu Li, Wenjun Xiao, Zhigang Li   +4 more
wiley   +1 more source