Model showing decline in HKDC1 gene expression with aging. In a young cell, TFEB gets recruited to its binding sites on the HKDC1 promoter to upregulate HKDC1 expression, which interacts with mitochondria and stabilizes PINK1 to maintain mitochondrial health.
Zeenat Farooq +8 more
wiley +1 more source
Bioactive Protein Profile and Compositional Evolution of Donkey Milk Across Lactation Reflecting Its Nutritional and Functional Food Value. [PDF]
Plotuna AM +7 more
europepmc +1 more source
Screening, optimization and characterization of exopolysaccharides produced by novel strains isolated from Moroccan raw donkey milk. [PDF]
Derdak R +9 more
europepmc +1 more source
AMUSE Livestock, version 2―Antimicrobial use in livestock production: A tool to harmonise data collection on knowledge, attitude and practices [PDF]
Alemu, Biruk +11 more
core
ABSTRACT Aim Biallelic inactivating WDR72 variants are linked to distal renal tubular acidosis (dRTA), nephrocalcinosis, and amelogenesis imperfecta. The kidney shows high WDR72 expression; its precise localization and function remain unclear. WDR72 is a member of the WD40 repeat domain protein family—a large group of scaffold proteins involved in ...
Hannah Auwerx +4 more
wiley +1 more source
Calponin‐3 is associated with epilepsy through the regulation of astrocyte activity
Increased calponin‐3 expression correlates with astrocyte activation in epileptic mice, modulating adenosine metabolism regulators ADK and ENT1. Calponin‐3 overexpression increased susceptibility to epileptic seizures, while its downregulation reduces spontaneous recurrent seizures, identifying it as a potential therapeutic target for epilepsy ...
Lu Chen +12 more
wiley +1 more source
Donkey milk-derived exosomes protect against UVB irradiation-induced ferroptosis in skin cells: <i>in vitro</i> and <i>in vivo</i> evidence. [PDF]
Yu J +8 more
europepmc +1 more source
NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia [PDF]
Araki, Toshiyuki +6 more
core +2 more sources
Loanwords in Finnish Quiz [PDF]
A nine-part quiz that features words that have been borrowed into the Finnish language before the 20th century. The quiz helps students to learn to recognise loanwords. Students will also acquire new vocabulary and have fun.
Valijarvi, Riitta-Liisa
core
Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari +6 more
wiley +1 more source

