Results 11 to 20 of about 636 (93)

Convenient Synthesis of Functionalized Cyclopropa[c]coumarin-1a-carboxylates

Molecules, 2018
A simple method has been developed for the synthesis of cyclopropa[c]coumarins, which belong to the donor-acceptor cyclopropane family and, therefore, are promising substrates for the preparation of chromene-based fine chemicals. The method, based on the
Olga A. Ivanova, Vladimir A. Andronov, Irina I. Levina, Alexey O. Chagarovskiy, Leonid G. Voskressensky, Igor V. Trushkov   +5 more
doaj   +1 more source

Diastereo- and enantioselective [3 + 3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones

Nature Communications, 2017
Chiral spirocyclic compounds are important structural motifs for drug discovery. Here, the authors report a synthetic route to spirocycles based on enantioselective cycloaddition of activated spirocyclopropyl oxindoles, which act as donor-acceptor ...
Peng-Wei Xu, Jia-Kuan Liu, Lan Shen, Zhong-Yan Cao, Xiao-Li Zhao, Jun Yan, Jian Zhou   +6 more
doaj   +1 more source

The Diarylprolinol Silyl Ethers: After 20 Years Still Opening New Doors in Asymmetric Catalysis

Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.
Catalysis Rules! The year 2025 marks the 20th anniversary of diarylprolinol silyl ethers in asymmetric organocatalysis. During the first decade after their discovery, these catalysts have been established as one of the most versatile tools in aminocatalysis. Although now considered mature, recent years have witnessed renewed innovation.
Enrico Marcantonio, René Slot Bitsch, Karl Anker Jørgensen   +2 more
wiley   +2 more sources

Cyclopropanes and Hypervalent Iodine Reagents: High Energy Compounds for Applications in Synthesis and Catalysis

CHIMIA, 2011
One of the major challenges faced by organic chemistry is the efficient synthesis of increasingly complex molecules. Since October 2007, the Laboratory of Catalysis and Organic Synthesis (LCSO) at EPFL has been working on the development of ...
Davinia Fernández González, Filippo De Simone, Jonathan P. Brand, Stefano Nicolai, Jérôme Waser   +4 more
doaj   +1 more source

Cyclization of Cyclopropyl Carbonyls and the Homo-Nazarov Reaction

CHIMIA, 2009
Ring strain confers exceptional reactivity to the cyclopropane ring. Nevertheless, activation of the cyclopropane ring is usually needed to allow ring-opening reactions under mild conditions.
Filippo De Simone, Jérôme Waser
doaj   +1 more source

4b,5,6,9-Tetrahydro-7H-dibenzo[c,e]pyrrolo[1,2-a]azepin-7-one

Molbank, 2019
A simple approach to synthesize 4b,5,6,9-tetrahydro-7H-dibenzo[c,e]pyrrolo[1,2-a]azepin- 7-one has been developed, based on a three-step transformation of 2-(2-bromophenyl)cyclopropane-1,1-diester.
Maksim A. Boichenko, Igor Yu. Babkin, Sergey G. Kobylskoy, Alexey O. Chagarovskiy, Olga A. Ivanova, Igor V. Trushkov   +5 more
doaj   +1 more source

(Poly)Borylated Species as Modern Reactive Groups toward Unusual Synthetic Applications

Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.
In this review, we spotlight recent breakthroughs in α‐polyboron‐substituted carbon‐centered intermediates (carbanion, carbocation, radical, and carbene) and polyborylated alkenes. By bridging fundamental reactivity with the application potential of these extraordinary species, we hope this review will serve as a roadmap for harnessing these unique ...
Nadim Eghbarieh, Nicole Hanania, Pinaki Nad, Tipu Alam, Tamir Kish, Ahmad Masarwa   +5 more
wiley   +2 more sources

PCA‐Based Database Mining Enables the Discovery of Bacterial Carbene Transferases for Stereodivergent Cyclopropanation

Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.
Database mining using principal component analysis (PCA)‐based clustering enabled discovery of bacterial enzymes capable of catalyzing stereodivergent cyclopropanation of styrene. Statistical analyses of sequence data further revealed characteristic structural properties of these enzymes, highlighting the potential of the bioinformatics tools for ...
Shunsuke Kato, Koki Takeuchi, Kohei Umeda, Hisashi Kudo, Tomohisa Hasunuma, Takashi Hayashi   +5 more
wiley   +2 more sources

On the Discorhabdins Leading to the Aleutianamine Ring System: A One‐Step in Situ Transformation Characterized Through Computational and Experimental Studies and Its Implications on Biosynthesis, Synthesis, and Pharmacology

Angewandte Chemie International Edition, EarlyView.
The thiocarbenium ion rearrangement of 3‐dihydrodisorhabdin B greatly increases the recovery of aleutianamine from Latrunculia spp., a pyrroloiminoquinone natural product with potent activity against drug‐resistant cancers, collected from the deep‐ocean along the Aleutian Islands.
Cody F. Dickinson, Abhay Potluri, Alison M. Bland, Samuel M. Flipse, George S. Hanna, Ryan T. Wagner, Keith D. Robertson, Thai H. Ho, Daniel J. Sprague, Gerald R. Hoff, Robert P. Stone, Marcus A. Tius, Dean J. Tantillo, Mark T. Hamann   +13 more
wiley   +1 more source

Pd‐Catalyzed C─C Bond Borylation of Biphenylenes Leading to Tri‐Ortho‐Substituted Biaryls

Chemistry – A European Journal, EarlyView.
Palladium‐catalyzed ring‐opening C─C borylation of 1‐substituted biphenylenes yields a range of o,o,o′‐trisubstituted biaryls with two ortho‐boryl groups via selective cleavage of the least hindered C─C bond. The resulting diborylated products are readily amenable to sequential, site‐selective postfunctionalization.
Robyn V. Presland, Konstantin V. Luzyanin, Luke A. Wilkinson, Oliver L. Jacobs, Nathan R. Halcovitch, Alexey G. Sergeev   +5 more
wiley   +1 more source