Results 281 to 290 of about 135,837 (338)

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

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Microbiological Screening of Donor Human Milk

Breastfeeding Medicine, 2023
Mother's own milk is recognized as the optimal feeding not only for term but also for preterm infants. In addition to risk reduction for sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, and retinopathy of prematurity in the early infancy, feeding preterm infants with mother's own milk is also associated with a better neurodevelopmental ...
Christine Schreiner, Andreas Müller, Till Dresbach   +2 more
openaire   +2 more sources

Human Donor Milk in Maternity

British Journal of Midwifery, 2023
Ines Salmoral and Denise McGuinness reflect on whether human donor milk should be made available for healthy term infants in the maternity setting
Ines Salmoral, Denise McGuinness
openaire   +1 more source

Characterization of Human Milk Donors

Journal of Human Lactation, 2007
The primary objective of this research was to create a detailed characterization of human milk donors, including descriptive information about demographics and lifestyle, involvement with the milk bank, reasons for donating, problems encountered while breastfeeding and pumping milk, barriers to donating milk, affective experiences, and personal values.
Richard, Osbaldiston, Leigh A, Mingle
openaire   +2 more sources

Immunomodulatory Constituents of Human Donor Milk

Breastfeeding Medicine, 2020
Mother's own human milk is the best nutrition for infants, especially preterm very-low-birth-weight (VLBW) (≤1,500 g) infants, because of its immune-modulatory constituents that strengthen the infant's host defense, provide protection against infections, and decrease the risk of necrotizing enterocolitis (NEC).
openaire   +2 more sources

Macronutrient content of donor human breast milk

Archives of Disease in Childhood - Fetal and Neonatal Edition, 2013
Background Nutritional analysis of donated human milk has been suggested as a means of optimising its use. Methods We analysed pooled, single donor milk samples using the MIRIS Human Milk Analyser to obtain values for fat, protein, lactose and ...
Andrew Ross, Cooper, Debbie, Barnett, Emma, Gentles, Lorraine, Cairns, Judith Helen, Simpson   +4 more
openaire   +2 more sources

Donor and recipient safety in human milk banking

Journal of Paediatrics and Child Health, 2022
AimAustralian Red Cross Lifeblood supplies pasteurised donor human milk (PDHM) to more than 30 partner hospitals across Australia. Preterm infants who receive PDHM are a highly vulnerable population but formal biovigilance programs are rare in human milk banking.
Vanessa Clifford, Laura D Klein, Richard Brown, Christine Sulfaro, Veronica Hoad, Iain B Gosbell, Joanne Pink   +6 more
openaire   +3 more sources