Results 251 to 260 of about 8,564,356 (290)

Donor-specific antibody to trans-encoded donor HLA-DQ heterodimer

Human Immunology, 2015
The majority of de novo donor specific HLA antibodies (DSAs) in transplant patients are directed to HLA-DQ antigens, which consist of a heterodimer of alpha and beta chains. Although a heterodimer can theoretically be cis- or trans-encoded, the sensitizing forms generally appear to be forms. DSA to DQ trans-heterodimer has never been reported.
Dennis F, Habig, Justine L, Gaspari, Parvez M, Lokhandwala, Ronald E, Domen, Catherine S, Abendroth, Zakiyah, Kadry, Nasrollah, Ghahramani, Riaz Ali, Shah, Ashokkumar, Jain, Hiroko, Shike   +9 more
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Significance of Donor-Specific Antibodies in Acute Rejection

Transplantation Proceedings, 2005
Significant advances in recent years in the diagnosis of antibody-mediated graft rejection have led to the re-evaluation of humoral alloreactivity in organ transplantation. By introducing the "C4d-test" into the work-up of transplant biopsies, donor-specific antibodies were claimed to be directly involved in about 30% of acute rejection episodes.
openaire   +2 more sources

Safety of Crossing Donor-specific Antibodies in Lung Transplantation

Transplantation, 2022
Background. Donor-specific antibodies (DSAs) have been associated with antibody-mediated rejection, chronic lung allograft dysfunction (CLAD), and increased mortality in lung transplant recipients. Our center performs transplants in the presence of DSA, and we sought to evaluate the safety of this practice with respect to graft
Melissa, Wang, Patricia, Campbell, Dale C, Lien, Rhea, Varughese, Justin, Weinkauf, Jayan, Nagendran, Alim, Hirji, David, Li, Kieran, Halloran   +8 more
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Donor-specific antibodies and antibody-mediated rejection in vascularized composite allotransplantation

Current Opinion in Organ Transplantation, 2016
The presence of donor-specific antibodies (DSA) increases the risk of graft failure. Although DSA characteristics, human leukocyte antigen class specificity, mean fluorescence intensity and immunoglobulin G subclasses, and their impact on the graft are quite well studied in solid organ transplants, very little information is known about their impact on
Annemarie, Weissenbacher, Alexandre, Loupy, Anil, Chandraker, Stefan, Schneeberger   +3 more
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Impact of donor-specific antibodies on results of liver transplantation

Current Opinion in Organ Transplantation, 2013
To critically examine the recent literature evaluating the importance of HLA donor-specific antibody (DSA) impact on liver transplant and simultaneous liver-kidney transplant (SLKT) outcomes.Many preformed DSAs, especially of low mean fluorescence intensity (MFI), are absorbed by the liver at transplant. However, patients with post-liver transplant DSA,
Jacqueline G, O'Leary, Göran B, Klintmalm   +1 more
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Donor-specific antibodies in allograft recipients

Current Opinion in Organ Transplantation, 2014
Kidney transplantation remains the treatment of choice for patients with end-stage renal failure. However, despite significant advancements in detection of donor-specific human leukocyte antigen antibodies, improved immunosuppression and patient management, the durability of this life-saving therapy has not improved. This results in increased morbidity
Stanley C, Jordan, Ashley A, Vo
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The clinical impact of donor-specific antibodies in heart transplantation

Transplantation Reviews, 2018
Donor-specific antibodies (DSA) are integral to the development of antibody-mediated rejection (AMR). Chronic AMR is associated with high mortality and an increased risk for cardiac allograft vasculopathy (CAV). Anti-donor HLA antibodies are present in 3-11% of patients at the time of heart transplantation (HTx), with de novo DSA (predominantly anti ...
Markus J. Barten, Uwe Schulz, Andres Beiras-Fernandez, Michael Berchtold-Herz, Udo Boeken, Jens Garbade, Stephan Hirt, Manfred Richter, Arjang Ruhpawar, Tim Sandhaus, Jan Dieter Schmitto, Felix Schönrath, Rene Schramm, Martin Schweiger, Markus Wilhelm, Andreas Zuckermann   +15 more
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Using Donor-Specific Antibodies to Monitor the Need for Immunosuppression

Transplantation, 2012
Experience with tolerance protocols has shown that none is perfect and that each escape from tolerance must be identified early to prevent graft failure. In addition, some test is needed for patients who are weaned off immunosuppression (IS) to forewarn of weaning failure.
Junichi, Hoshino, Hugo, Kaneku, Matthew J, Everly, Sander, Greenland, Paul I, Terasaki   +4 more
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The meaning of donor-specific antibodies after heart transplant

Current Opinion in Organ Transplantation, 2019
Purpose of review Antibody-mediated rejection (AMR) is a major contributor of impaired long-term survival after heart transplantation (HTx). The presence of circulating donor-specific antihuman leukocyte antigen (HLA) antibodies (DSAs) is considered as a mandatory criterion for AMR after HTx. DSA are known prognostic biomarkers
Markus J, Barten, Andreas, Zuckermann
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Donor-Specific Antibodies: Clinical Relevance of Antibodies Detected in Lymphocyte Crossmatches

Clinics in Laboratory Medicine, 1991
Positive donor crossmatches due to lymphocytotoxic antibodies generally have an adverse effect on allograft survival, but with numerous variations. Different laboratory techniques used to characterize lymphocytotoxic antibody, new antibody systems, such as those incited by endothelial/monocyte and epithelial antigens, the variable tempos and ...
openaire   +2 more sources