Results 161 to 170 of about 58,036 (310)

Heterologous expression of hydroxylase coupled with pathway optimization enables highly efficient ʟ-DOPA production in <i>Corynebacterium glutamicum</i>. [PDF]

Synth Syst Biotechnol
Jia M, Duan R, Jiang Y, Chu X, Wu X, Yang H, Ye B, Zhang B.   +7 more
europepmc   +1 more source

Severe Lower Limb and Abdominal Edema Associated with Subcutaneous Apomorphine Infusion

Movement Disorders Clinical Practice, EarlyView.
Guillaume Costentin, David Maltête
wiley   +1 more source

Spatiotemporal Progression Patterns of Striatal Dopamine Depletion and Cerebral Hypoperfusion in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background The identification of Parkinson's disease (PD) subtypes is crucial for predicting the disease course and designing personalized therapeutic strategies. Objectives The aim of the study was to characterize the heterogeneity of the spatiotemporal evolutionary patterns of striatal dopamine depletion and cerebral hypoperfusion in PD ...
Yeeun Sun, Youngseok Choi, Chan Wook Park, Han Kyu Na, Hye Sun Lee, Yun Joong Kim, Young H. Sohn, Phil Hyu Lee, Jeyeon Lee, Seok Jong Chung   +9 more
wiley   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Regional dopaminergic dysfunction patterns discriminate Parkinson's disease from multiple system atrophy parkinsonian subtype. [PDF]

Clin Park Relat Disord
Xu D, Jia C, Zhang T, Ren C, Zhu W, Wang H, Huo L.   +6 more
europepmc   +1 more source

Improve the Thermal Conductivity, Insulation Performance and Mechanical Properties of Silicone Rubber by Constructing EG‐PDA‐Cu Hybrid Nanoparticles

Journal of Polymer Science, EarlyView.
In this work, a novel expanded graphite‐supported nano‐copper polydopamine composite was designed and synthesized. The procedure involved first modifying EG via a mussel‐inspired technique to deposit a polydopamine coating, after which Cu2+ ions were reduced to immobilize copper nanoparticles onto the EG‐PDA substrate.
Xingrong Liu, Fan Xia, Dietmar Auhl
wiley   +1 more source

Dopamine 2 receptor ablation from cholinergic neurons attenuates L-DOPA induced dyskinesias. [PDF]

Front Aging Neurosci
Uribe-Cano S, Malave L, Kottmann AH.
europepmc   +1 more source

Current Insight into Human Ornithine Aminotransferase: A Review

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Human ornithine aminotransferase (hOAT) is a mitochondrial matrix pyridoxal‐5′‐phosphate enzyme (PLP) that catalyzes the reversible transfer of the δ‐amino group of L‐ornithine (L‐Orn) to α‐ketoglutarate (α‐KG) yielding glutamate‐5‐semialdehyde (GSA) and glutamate. GSA is prone to cyclize to Δ1‐pyrroline‐5‐carboxylate.
Fulvio Floriani, Carla Borri Voltattorni, Riccardo Montioli   +2 more
wiley   +1 more source

Investigation of the Effects of Saffron on Neuroprotection and Circadian Rhythm in an <i>In Vitro</i> Parkinson's Model. [PDF]

Pharmaceuticals (Basel)
Aksoy A, Usta DD, Yar AS.
europepmc   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source